A DNA-templated synthesis of encoded small molecules by DNA self-assembly

We report a novel method for the synthesis of DNA-encoded libraries without the need for discrete DNA template. Reactant DNAs self-assemble to enable chemical reactions and photo-cleavage transfers the product to the DNA terminus, making it suitable for the subsequent affinity-based selection and hit deconvolution.Chemistry, MultidisciplinarySCI(E)2ARTICLEyu.bai@pku.edu.cn; xiaoyuli@pku.edu.cn7510997-109995