The prospective study project of 62 cases spinal cord injury

目的:通过前瞻性研究设计,对影响脊髓损伤患者功能恢复的各种影响因素进行初步分析.方法:设计前瞻性队列研究方案,在不干涉临床治疗方案前提下,采集2006年12月至2007年12月收治的脊髓损伤患者资料,纳入标准定为:急性脊髓损伤(受伤时间在1周以内),男女不限,年龄限定在18～65岁,根据临床查体结合MRI或CT检查证实为美国脊髓损伤协会(ASIA)分级标准(2000年修订)的A级(完全性脊髓损伤,损伤平面下不存在任何运动和感觉功能)或者B级(不完全性脊髓损伤,损伤平面下不存在运动功能,但存在感觉功能).所有入选病例均获随访,并分别在受伤入院当时及第1次评估后1、3、6个月采用ASIA分级标准、功能独立性评测(FIM)评价脊髓损伤及恢复情况,分析影响脊髓损伤患者功能恢复的因素.结果:共入选62例患者,男性60例,女性2例;年龄18～41岁,平均24岁;A级损伤29例,B级损伤33例.A级损伤中,手术减压患者(手术组)和非手术减压患者(非手术组)的感觉、运动ASIA评分及FIM评分比值在术后各时间点上的差异无统计学意义(P>0.05),B级损伤中,手术组和非手术组在手术前后感觉、运动ASIA评分、FIM评分的比值在各个时间点上差异均具有统计学意义(P<0.05).在手术组患者中,减压手术在伤后8 h以内(≤8 h)进行者,术前和术后感觉、运动ASIA评分、FIM评分比值与在伤后8 h以外(>8 h)进行者相比差异具有统计学意义(P<0.05).结论:对于A级损伤,手术减压时间点的选择对损伤的脊髓功能恢复影响差别不大,考虑到护理的方便和维持脊柱稳定性的要求,可以选择减压内固定手术;对于B级损伤,应该尽早进行减压手术以最大程度地恢复损伤脊髓的功能.Objective To rudiment analyze the different intervention factors affecting the spinal cord injury functional recovery initially through prospective study project. Methods Designed prospective study project without clinical treatment intervention and admitted 62 spinal cord injury cases into observation group from Dec 2006 to Dec 2007. The internalized standard included acute spinal cord injury within 1 week, aged from 18 to 65 years old without sexuality difference and diagnosed as type A injury: total spinal cord injury or type B injury: non-total spinal cord injury (without movement function below the injury plane) according to clinical physical examination and combined MRI or CT examination. All the 62 cases were followed up. The spinal cord function were estimated at the time of arriving hospital, 1,3,6 months after injury during the following up time according to the American Spine Injury Association standard ( Revised at 2000) and functional independence measure(FIM) score. The intervention factors affecting the spinal cord injury functional recovery were analyzed. Results Among the 62 cases, male 60 cases and female 2 cases, aged from 18 to 41 years old, mean age 24 years old, 29 cases can be classified into type A injury and 33 cases can be classified into type B injury. There was no significant difference (Index including sense ASIA, motor ASIA and FIM) between operation group and non-operation group, namely conservatively composite treatment at all observation point in all type A injury cases ( P > 0. 05 ). There was significant difference (Index including sense ASIA,motor ASIA and FIM) between operation group and non-operation group at all observation point in all type B injury cases(P<0.05 ) ;And there was significant difference (Index including sense ASIA,motor ASIA and FIM) between operated in 8 hours (≤8 h) group and beyond 8 hours ( >8 h) group at all observation point in all type B operated cases ( P <0.05 ). Conclusions Operation and operation time were of no significant value for type A injury (total spinal cord injury), but considering the nursing convenience and the need for spinal stabilities, operation decompression and internal fixation can be chosen; Operation decompression should be performed as soon as quickly for type B injury (non-total spinal cord injury) in order to get better functional recovery.国家杰出青年科学基金; 国家重点基础研究发展规划(973计划)中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)06461-4644