An analysis of 49 cases of patients with sysmetic lupus erythematosus and pregnancy

目的 探讨系统性红斑狼疮(SLE)患者的妊娠时机及其对母婴的影响.方法 对1992年12月至2012年2月在我院住院的SLE合并妊娠患者的临床资料进行回顾性分析.率的比较采用x2检验.结果 49例SLE患者共妊娠52次.按照选择性妊娠与非选择性妊娠分组,选择性妊娠组27例,活产24例(89％),早产3例(12％),低出生体质量儿4例(17％),妊娠期疾病出现活动5例(18％)；非选择性妊娠组25例,活产12例(48％),早产6例(50％),低出生体质量儿6例(50％),妊娠期疾病出现活动20例(80％).选择性妊娠组活产率明显高于非选择性妊娠组(P＜0.01),早产率明显低于非选择性妊娠组(P＜0.05),妊娠期间疾病活动明显少于非选择性妊娠组(P＜0.01).结论 SLE患者选择适当的妊娠时机,妊娠期间加强风湿免疫科及产科的监护,可以提高活产率,降低妊娠期间病情活动和早产率.Objective To investigate the pregnancy opportunity and outcome of patients with sysmetic lupus erythematosus (SLE).Methods We carried out a retrospective analysis of the clinical information of patients who suffered from SLE complicated with pregnancy and were hospitalized to People's Hospital of Peking University from December of 1992 to February of 2012.Chi-square test were used for statistical analysis.Results Forty-nine cases of patients with SLE complicated with pregnancy had 52 pregnancies in total.In 27 cases of planned pregnancies,24 cases(89％ )resulted in live births and 5 cases( 18％ ) had flares during pregnancy.Of the 24 live births,3 cases( 12％)were premature deliveries and 4 cases(17％) had low birth weight infants.In 25 cases of unplanned pregnancies,12 cases (48％) resulted in live births and 20 cases (80％) had flares during pregnancy.Of the 12 live births,6 cases(50％ ) were premature deliveries and 6 cases (50％) were low birth weight infants.The patients in the planned pregnancy group tended to have flares during pregnancy more frequently than those in the unplanned group (P＜0.01),the former were more likely to have live births than the latter (P＜0.01) and were less likely to have premature delivery (P＜0.05).Conclusion Patients with SLE should have planned pregnancy and need collaborative supervision of both rheumatology and immunology department and obstetric department to improve live birth rate,decrease premature delivery and the activity of SLE during pregnancy.中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)08553-5561