The differences and similarities between polypoidal choroidal vasculopathy and age related macular degeneration is worthy for further investigation

息肉样脉络膜血管病变(PCV)是以视网膜下出血、视网膜色素上皮脱离和神经上皮脱离为特征的渗出性黄斑病变,占我国新生血管性老年性黄斑变性(AMD)患者的33.5％.吲哚青绿血管造影检查发现脉络膜来源的单个或多个结节样强荧光为当前PCV诊断的金标准.组织病理学检查显示脉络膜毛细血管透明样变,与动脉硬化表现相似;基因研究目前尚未发现PCV与AMD的区别;环境因素显示高血压与PCV的相关性超过与AMD的相关.PCV与AMD是不同的基因型还是相同的基因产生不同的表型,以及两种疾病发病机制的异同均有待进一步的研究.Polypoidal choroidal vasculopathy (PCV) is one of the exudative maculopathy,which is characterized by retinal pigment epithelium detachment,subretinal hemorrhages and sensory retinal detachment.The prevalence of polypoidal choroidal vasculopathy (PCV) reached 33.5％ in neovascular age related macular degeneration (AMD) for Chinese population.Indocyanine green angiography showed a single or multiple focal nodular areas of hyperfluorescence arising from the choroidal circulation and currently is recognized a gold standard for diagnosis of PCV.The histopathologic findings indicated that hyalinization of choroidal vessels,like arteriosclerosis.Up to now there is no reliable evidence to demonstrate the difference in genetic study.The study of environment factor showed hypertension is associated with PCV closely than with AMD.PCV and AMD is different genotype or different phenotype as well as difference in pathogenesis need further studies.国家重点基础研究发展计划中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)05433-4352