Analysis of the clinical features of type 2 diabetes mellitus patients complicated with coronary heart disease

目的 比较有否合并冠心病(CHD)的糖尿病(DM)患者的临床特点,为预测DM患者发生CHD的危险性提供参考依据.方法 将336例DM患者分为CHD组(267例)和非冠心病(non-CHD)组(69例).比较两组患者的一般情况、血脂、糖代谢等生化指标和炎症指标的差异.并通过logistic回归筛选DM患者CHD的独立危险因素.结果 两组相比,DM病程、吸烟史、腰臀比、HDL-C、FPG、HbA1c、肌酐、hsC-RP、WBC和中性粒细胞百分比存在统计学差异.其中,DM病程、吸烟史、HDL-C和FPG是DM患者发生CHD的独立危险因素,比值比分别为0.925、3.576、2.839和0.819.结论 DM病程长、有吸烟史、HDL-C水平低、FPG水平高的DM患者合并CHD的可能性更大.Objective To analyze the clinical features of type 2 diabetes mellitus(DM)patients complicated with coronary heart disease(CHD).Methods 336 DM patients undergoing coronary angiography were divided into two groups:DM with CHD(n=267)and DM without CHD(n=69).General conditions,lipid profiles,glycemic control,other serum biochemical parameters and inflammatory parameters were detected and compared.And then,logistic regression analysis was used to find the independent risk factors for CHD in DM patients.Results There were several differences between DM with and without CHD in parameters including DM duration(P=0.038),smoking history(P=0.000),W/H ratio(P=0.000),HDL-C(P=0.006),FPG(P=0.000),HbA1c(P=0.000),CREA(P=0.006),hs-CRP(P=0.011),WBC(P=0.000)and NEU%(P=0.000).But only 4 parameters,including DM duration(OR=0.925),smoking history(OR=3.576),HDL-C(OR=2.839)and FPG(OR=0.819)were independent risk factors.Conclusion The DM patients who have long DM duration,smoking history,poor glycemic control and reduction of HDL-C are inclined to suffer CHD.中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)04208-2101