Relationship Between α1 Adrenergic Receptor Subtypes and Detrusor Instability Induced by Bladder Outlet Obstruction in Rats

秦峰
徐涛
王晓峰

Open link

Publication date

January 2009

DOI

10.3969/j.issn.1001-1420.2009.02.025

Publisher

临床泌尿外科杂志

Journal

1001-1420

Abstract

目的:探讨肾上腺素α1受体亚型与大鼠膀胱出口梗阻(BOO)所致逼尿肌不稳定(DI)的关系.方法:利用雄激素诱导前列腺肥大建立雄性SD大鼠膀胱出口梗阻模型,梗阻6周后行充盈性膀胱测压、离体逼尿肌条收缩实验及Western Blotting蛋白印迹实验.结果:BOO动物模型梗阻6周后逼尿肌不稳定的发生率为90%,DI组与对照组相比,排尿压力升高,(69.30&#177;9.90)vs(49.60&#177;8.36)cmH2O(P<0.05).剩残余尿量增加(0.29&#177;0.07)vs(0.10&#177;0.05)ml(P<0.05).膀胱容量增加(0.59&#177;0.07)vs(0.23&#177;0.05)ml(P<0.05).肌条收缩力升高(0.89&#177;0.07)vs(0.43&#177;0.05)g(P<0.05).α1D受体蛋白表达程度高于对照组,α1A受体表达程度末发生变化.结论:肾上腺素α1D受体主要参与到大鼠膀胱出口梗阻后逼尿肌不稳定的发生发展中.中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)02148-149,1522

Extracted data

We use cookies to provide a better user experience.

Data Protection

Relationship Between α1 Adrenergic Receptor Subtypes and Detrusor Instability Induced by Bladder Outlet Obstruction in Rats

Abstract

Extracted data

Relationship Between α1 Adrenergic Receptor Subtypes and Detrusor Instability Induced by Bladder Outlet Obstruction in Rats

Abstract

Extracted data

Related items

Related items