Comparison of pantoprazole and omeprazole-based triple therapy regimens in the treatment of Helicobacter pylori infection

目的研究泮托拉唑三联疗法与奥美拉唑三联疗法及其1周与2周疗法根除幽门螺杆菌(Helicobacter pylori, Hp)的效果.方法 147例经胃镜证实的Hp阳性的重度胃炎患者,随机分成泮托拉唑三联组(n=82).(泮托拉唑 40 mg+阿莫西林 1 g+甲硝唑 400 mg,日2次,疗程1或2周)和奥美拉唑三联组(n=65)(奥美拉唑20 mg +阿莫西林 1 g+甲硝唑 400 mg,日2次,疗程1或2周).疗程结束4周后复查Hp,观察Hp根除率、症状缓解率及不良反应等.结果泮托拉唑三联与奥美拉唑三联疗法Hp根除率1周分别为85.7%(42/49)和76.9%(20/26);2周为93.9%(31/33)和82.1%(32/39).结论泮托拉唑三联疗法1周与2周、奥美拉唑三联疗法1周与2周4组之间比较差异均无显著意义(P>0.05).To compare the efficacies of pantoprazole and omeprazole-based triple regimens in the treatment of H. pylori infection for 1-week or 2-week.147 patients with H. pylori associated gastritis were randomly divided into pantoprazole triple regimen group (pantoprazole 40 mg, amoxicillin 1 g, and metronidazole 400 mg, bid,for 1-week or 2-weeks) and omeprazole triple regimen (omeprazole 20 mg, amoxicillin 1 g, and metronidazole 400 mg, bid, for 1-week or 2-weeks). The eradication was determined by (13)C-UBT at least 4 weeks after antibiotic therapy.The eradication rate of H. pylori for 1-week pantoprazole triple regimen and omeprazole triple regimen were 85.7% (42/49) and 76.9% (20/26) respectively (P > 0.05). The eradication rates of H. pylori for 2-weeks and pantoprazole triple regimen and omeprazole triple regimen were 93.9% (31/33) and 82.1% (32/39) for 2-week respectively (P > 0.05).The eradication rate of H. pylori in pantoprazole (or omerazole) triple therapy regimen for 2-weeks was higher than 1-week. However there were no significant difference between in these two groups (P > 0.05). There were no significant difference between pantoprazole and omeprazole triple therapy regimen in eradication rate of H. pylori for 1-week or 2-weeks (P > 0.05).PubMed中文核心期刊要目总览(PKU)中国科学引文数据库(CSCD)0181245-12488