The Effects of Prucaloprideon Chronic Constipation

目的：分析普芦卡必利作为一种新型5-HT4激动剂对慢性便秘的治疗作用。方法：收集普芦卡必利治疗慢性便秘的文献，分析其疗效和安全性。结果与结论：普芦卡必利对慢性便秘，尤其对缓泻剂治疗失败的女性便秘患者是一个良好的治疗药物，对于其他动力紊乱性疾病也可能有效。截至目前的研究提示普芦卡必利的安全性良好。Objective: To analyze the efifcacy of Prucalopride, a novel 5-HT4 receptor agonist,in the treatment of chronic constipation.Methods: Current literatures regarding on the efficacy and the safety of prucalopridefor the treatment of chronic constipation were col ected and analyzed. Results and Conclusion: Prucalopride is an important medicine treating chronic constipation, especial y in females poorly responding to laxatives. There is also the possibility that it might be of beneift to other disorders of gastrointestinal motility. The safety proifle of the drug to date is favorable.中国科技核心期刊(ISTIC)0646-4