Study of predictive indicators and pregnancy outcome of poor ovarian response in controlled ovarian hyper-stimulation

目的：研究控制性超促排卵下卵巢低反应的预测指标及妊娠结局情况。方法：选择拟行IVF/ICSI助孕治疗的152名不孕症女性，根据卵巢反应性分为两组：低反应组（获卵数＜4个）、非低反应组（获卵数≥4个）。收集不孕症女性的相关临床资料进行分析。结果：卵巢低反应的发生率为18.42％（28/152）。两组中年龄、基础FSH值、FSH/LH值、AFC 有显著性差异。多因素Logistic 回归分析显示：年龄和AFC进入回归模型，年龄与卵巢反应性呈负相关，AFC与卵巢反应性成正相关。周期取消率为19.74％（30/152），卵巢低反应组（35.71％，10/28）明显高于非低反应组（16.13％，20/124）。移植周期临床妊娠率为51.64％（63/122），卵巢低反应组（22.22％，4/18）明显低于非低反应组（56.73％，59/104）。结论：年龄和AFC可用于卵巢低反应的预测。卵巢低反应可导致周期取消率升高、临床妊娠率降低。Objectives:To study the predictive indicators and pregnancy outcome of poor ovarian response in controlled ovarian hyperstimulation.Methods:A total of 152 infertile women undergoing IVF/ICSI were included in this study and divided into 2 groups according to the number of retrieved oocytes:poor ovarian responders (<4 oocytes);non-poor ovarian responders (≥4 oocytes).Clinical data,including age,duration of infertility,basal follicle stimulating hormone (FSH)level,antral follicle count (AFC),total dosages of gonadotropins (Gn),total number of retrieved oocytes,and clinical pregnancy outcome were obtained.Results:The incidence of poor ovarian response was 18.42% (28/152).There was significant difference in age,basal FSH,FSH/LH,AFC between poor and non-poor ovarian response.Multi-variate Logistic regression analysis showed a negative correlation be-tween age and ovarian response,and a positive correlation between AFC and ovarian response.In this study,the cy-cle cancellation rate in poor ovarian response (35.71%,10/28)was higher than that of non -poor response (16.13%,20/124).The clinical pregnancy rate in poor ovarian response (22.22%,4/18)was lower than that of non-poor response (56.73%,59/104).Conclusions:Age and AFC can be used as predictive indicators of poor o-varian response.Poor ovarian response may result in higher cycle cancellation rate and lower clinical pregnancy rate.中国科技核心期刊(ISTIC)01076-7