Effect of triamcinolone acetonide and econazole nitrate cream versus mometasone furoate cream on prognosis of persistent localized eczema

目的比较曲安奈德益康唑乳膏与糠酸莫米松乳膏治疗持续性局限性湿疹的疗效与安全性及其对复发的影响。方法门诊持续性局限性湿疹患者220例，随机分两组，分别外用曲安奈德益康唑乳膏和糠酸莫米松乳膏，均治疗4周。达到临床治愈者随访24周，观察复发情况。结果急性及亚急性湿疹患者接受4周治疗后，曲安奈德益康唑组痊愈率（100％）高于糠酸莫米松组（57.9％），差异有统计学意义（ P＝0.005）。治疗慢性湿疹4周，曲安奈德益康唑组痊愈率与糠酸莫米松组差异无统计学意义（χ2＝0.224，P＝0.636）。曲安奈德益康唑组不良反应发生率（2.73％）与糠酸莫米松组（1.82％）差异无统计学意义（χ2＝0.000，P＝1.000），无严重不良反应。二者总复发率差异也无统计学意义（29.6％ vs．33.8％，χ2＝0.289， P＝0.591）。结论曲安奈德益康唑乳膏治疗急性亚急性湿疹疗效优于单方激素糠酸莫米松，在治疗慢性湿疹及预防复发方面二者相当。Objective To compare the efficacy and safety between triamcinolone acetonide and econazole nitrate cream and mometasone furoate cream in the treatment of persistent localized eczema and their effect on recurrence.Methods 220 outpatients with localized eczema were randomized to treatment for 4 weeks with triamcinolone acetonide and econazole nitrate cream or mometasone furoate cream .Those whose symptom score reducing index (SSRI) more than 90% were followed up until 24 weeks after the discontinuation to observe the recurrence.Results After 4 weeks treatment the cure rate of triamcinolone acetonide and econazole nitrate group were significantly higher than that of mometasone furoate group in patients with acute and subacute eczema ( 100%vs.57.9%,chi-square test,P =0.005).There was no significant difference between the cure rates of these two groups in patients with chronic eczema after 4 weeks of treatment (χ2 =0.224 ,P=0.636 ) .No significant difference was found in the incidence rates of adverse effect between the two groups ( 2.73% vs.1.82%,χ2 =0.000 , P =1.000 ) .The adverse effects were mild .There was no significant difference between the recurrence rates of these two groups(29.6%vs.33.8%,χ2 =0.289,P=0.591).Conclusions Triamcinolone acetonide and econazole nitrate cream is superior to mometasone furoate cream in the treatment of acute and subacute eczema .The two creams are equal in the treatment of chronic eczema and preventing relapse of eczema .中国科技核心期刊(ISTIC)031097-110