Advances in biological prognostic indicators of chronic lymphocytic leukemia

慢性淋巴细胞白血病(CLL)预后个体差异大,在诊断初期对患者进行准确的预后判断,进而辅助制定治疗计划具有重要临床意义.近年来CLL预后指标如IgVH基因突变,ZAP70,CD_(38),细胞遗传学异常[t(11q;v)、del(11q)、del(17p)、+12和del(13q)],端粒和端粒酶等成为研究的热点,文章就其研究的新进展进行综述.The patients of chronic lymphocytic leukemia(CLL)have great individual differences.It is important for clinicians to determine the prognosis at the beginning of diagnosis and choose proper treatment for the patients.The recent advances in biological prognostic indicators of CLL were reviewed,including IgVH gene mutation status,ZAP70,CD_(38),chromosome abnormality[t(11q;v),del(11q),del(17p),+12 and del(13q)].telomere and telomerase.0155-581