New detection method of gastric endoscope samples using Fourier transform mid-spectroscopy

应用傅里叶变换红外光谱 ( FTIR)测定了 1 84例胃镜样品 ,总结不同病变类型组织的光谱特征 ,并与病理结果进行比较 .实验结果表明 ,由于不同类型病变组织会在其分子组成和结构上发生相应改变 ,浅表性胃炎、萎缩性胃炎和胃癌组织具有不同的 FTIR光谱 ,可据此进行胃镜样品疾病类型和病变程度的判别 .研究结果表明 ,FTIR技术有望发展成为一种用于胃镜样品无创、快速、准确的在体临床诊断的新方法 .A new detection method of gastric endoscope samples with promising perspective in clinical application was first proposed in this paper. The identification of stomach cancer, chronic atrophic gastritis and superficial gastritis for a total of 184 gastric endoscope samples was first investigated by using Fourier transform mid-infrared spectroscopy. The spectral characteristics for different classifications of gastric tissues were summarized and correlated with the corresponding pathological results. The experimental results indicated that the changes of molecular composition and structure with various diseases of stomach tissues occur, so the distinct differences were observed among the FTIR spectra of the normal, atrophic gastritis, superficial gastritis and malignant gastric tissues, which were used to classify the diseases and determine the degree of diseases of the gastric endoscope samples. The results demonstrate that FTIR method possesses promising perspective to be developed as a new non-invasive, rapid, accurate and in vivo gastric endoscope detection technique in clinical application.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000224014600011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701SCI(E)中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)4091624-16272