Studies on the relaxivities of novel MRI contrast agents two water-soluble derivatives of Gd@C-82
- 卢兴
- 徐建勋
- 施祖进
- 孙宝云
- 顾镇南
- 刘洪东
- 韩鸿宾
DOIAbstract
在 ( 3 7± 1 )℃下 ,以 1 .5 T自旋回波序列测得 2种 Gd@C82 的水溶性衍生物 [Gd@C82 ( OH) 2 2 和Gd@C82 ( OH) 6( NHCH2 CH2 SO3 H) 8]水溶液的质子弛豫率分别为 r1=42 .3 mmol-1· L· s-1,r2 =90 .9mmol-1·L· s-1;r1=4.5 mmol-1· L· s-1,r2 =8.9mmol-1· L· s-1.讨论了这 2种衍生物的弛豫机理 ,并解释了二者弛豫能力差别的原因 .The water proton relaxivities of two water-soluble derivatives of Gd@C-82[Gd@C-82(OH)(22) and Gd@C-82 (OH)(6) (NHCH2CH2SO3H)(8)] were determined to be r(1) = 42. 3 mmol(-1) (.) L (.) s(-1), r(2) = 90. 9 mmol(-1) (.) L (.) s(-1); r(1) = 4. 5 mmol(-1) (.) L (.) s(-1), r(2) = 8. 9 mmol(-1) (.) L (.) s(-1) respectively at (37 +/- 1) degreesC by a 1. 5 T spin-echo method. The relaxation mechanism was discussed and the reason why the relaxivities of Gd@C-82(OH)(22) is an order of magnitude higher than that o...
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