The Value of Health Management in Prevention and Treatment of Hyperhomocysteinemia

目的：探讨健康管理防治高同型半胱氨酸血症的价值。方法将健康体检中MTHFR C677T基因多态性伴HHcy、血脂异常增高者作为研究对象，随机分成对照组和观察组。两组在规范叶酸、维生素B6强化治疗的基础上，又对观察组实施个性化健康促进干预措施。结果对照组连续6个月药品强化治疗后，Hcy、血脂水平未明显下降，差异无统计学意义(P>0.05)。连续12个月药品强化治疗后，Hcy及血脂水平明显下降，差异有统计学意义(P<0.001,P<0.05)。观察组在个性化健康促进干预6个月、12个月后，Hcy及血脂水平显著降低，差异有统计学意义(P<0.001，P<0.001)。结论健康管理可显著降低MTHFR C677T基因多态性伴HHcy、血脂异常目标人群Hcy、血脂水平，提高服药依从性，这将有助于控制高危因素，预防脑血管疾病的发生。Objective To explore the value of health management in prevention and treatment of hyperhomocysteinemia.Methods The research object was people with MTHFR C677T gene polymorphism, HHcy and abnormal blood lipid had been screened in physical examination who were divided into a control group and a observation group. Two groups took specification of folic acid, vitamin B6 treatment, observation group to implement personalized health promotion interventions.Results Hcy and lipid of the control group was not signiifcantly lower in 6 months after drug treatment. There was no statistically signiifcant difference (P>0.05). Hcy and lipid of the control group was signiifcantly lower in 12 months after drug treatment.There was statistically signiifcant difference (P<0.001,P<0.05). Hcy and lipid of the observation group was signiifcantly lower in personalized health promotion intervention 6 months and 12 months later.There was statistically significant difference (P<0.001,P<0.001).Conclusion Health management can reduce the target population Hcy and lipid level, increase medication compliance, this will help to control the risk factors, prevent the happening of the cerebrovascular disease.健康管理对MTHFR C677T基因多态性人群卒中防治的影响研究，编号JCYJ201404151625430160255-57,6