将L-山梨糖的2,3位用异亚丙基保护、在6位上进行选择性苯磺酰化、叠氮化、催化氢化、水解得6-氨基-6-脱氧-L-呋喃山梨糖盐酸盐,再经催化氢化得1-脱氧氮杂-D-葡萄糖(deoxynojirimycin,DNJ)盐酸盐,总收率26%. 采用苄氧羰酰化,将DNJ及其差向异构体进行了分离,得到的N-苄氧羰酰基-1-脱氧氮杂-D-葡萄糖经氢解后生成1-脱氧氮杂-D-葡萄糖.国家自然科学基金中文核心期刊要目总览(PKU)中国科学引文数据库(CSCD)0112-152
publisher奈良L‐ラムノースは抗酸菌の細胞壁のペプチドグルカンとアラビノガラクタンとの結合点の構造［→４） ‐α‐L‐Rha‐(１→３)‐α‐D‐GlcNAc‐(１→］を構成する鍵になる化合物...
Предложен новый способ синтеза труднодоступных и стерически затрудненных N,N-диалкоксикарбаматов и N...
The value of methyl 3-O-benzyl-2,6-dideoxy-2,6-imino-α-D-mannofuranoside as a divergent intermediate...
This report deals with the formal synthesis of deoxynojirimycin using D-glucitol as an inexpensive s...
Highly stereoselective six-step syntheses of (−)-1-deoxyaltronojirimycin (<i>altro</i>-DNJ) and (+)-...
We recently described the discovery of oxygenated <i>N</i>-alkyl deoxynojirimycin (DNJ) derivative <...
The syntheses of nojirimycin δ-1actam and of deoxynojirimycin from a divergent ido-furanose intermed...
Deoxynojirimycins are an important class of iminosugars, which are closely related to natural carboh...
1-Deoxymannojirimycin (DMJ) has been investigated as a potential anti-cancer therapy due to its spec...
Over the years, the interest for the synthesis and pharmacological behavior of iminosugars, sugar an...
International audienceN6-Bis-demethylated deoxyxylopuromycin was synthesized over six steps in 56% o...
Herein a practical and scalable route to 1-deoxyaltronojirimycin is presented. The target is achieve...
Nuolat auganti nukleozidų paklausa skatina ieškoti įvairių jų sintezės būdų. Šiuo metu nukleozidai y...
报道了1,3-二(乙氧基甲基)-5-N,N-二甲氨基-6-甲基尿嘧啶方便、高产率的合成方法.以6-甲基尿嘧啶(1)为起始物,经硝化、嘧啶N1,N3-烷基化、还原及氨基甲基化,首次高产率合成了1,3-二...
研究1-烷基-5-氨基-6-苯乙基尿嘧啶(1a,1b)方便、高产率的合成方法,此类化合物有可能作为非核苷类HIV-1RT抑制剂.以6-甲基尿嘧啶(2)为起始物,经硝化、烷基化、苄基化及-锅反应脱苄基及...
publisher奈良L‐ラムノースは抗酸菌の細胞壁のペプチドグルカンとアラビノガラクタンとの結合点の構造［→４） ‐α‐L‐Rha‐(１→３)‐α‐D‐GlcNAc‐(１→］を構成する鍵になる化合物...
Предложен новый способ синтеза труднодоступных и стерически затрудненных N,N-диалкоксикарбаматов и N...
The value of methyl 3-O-benzyl-2,6-dideoxy-2,6-imino-α-D-mannofuranoside as a divergent intermediate...
This report deals with the formal synthesis of deoxynojirimycin using D-glucitol as an inexpensive s...
Highly stereoselective six-step syntheses of (−)-1-deoxyaltronojirimycin (<i>altro</i>-DNJ) and (+)-...
We recently described the discovery of oxygenated <i>N</i>-alkyl deoxynojirimycin (DNJ) derivative <...
The syntheses of nojirimycin δ-1actam and of deoxynojirimycin from a divergent ido-furanose intermed...
Deoxynojirimycins are an important class of iminosugars, which are closely related to natural carboh...
1-Deoxymannojirimycin (DMJ) has been investigated as a potential anti-cancer therapy due to its spec...
Over the years, the interest for the synthesis and pharmacological behavior of iminosugars, sugar an...
International audienceN6-Bis-demethylated deoxyxylopuromycin was synthesized over six steps in 56% o...
Herein a practical and scalable route to 1-deoxyaltronojirimycin is presented. The target is achieve...
Nuolat auganti nukleozidų paklausa skatina ieškoti įvairių jų sintezės būdų. Šiuo metu nukleozidai y...
报道了1,3-二(乙氧基甲基)-5-N,N-二甲氨基-6-甲基尿嘧啶方便、高产率的合成方法.以6-甲基尿嘧啶(1)为起始物,经硝化、嘧啶N1,N3-烷基化、还原及氨基甲基化,首次高产率合成了1,3-二...
研究1-烷基-5-氨基-6-苯乙基尿嘧啶(1a,1b)方便、高产率的合成方法,此类化合物有可能作为非核苷类HIV-1RT抑制剂.以6-甲基尿嘧啶(2)为起始物,经硝化、烷基化、苄基化及-锅反应脱苄基及...
publisher奈良L‐ラムノースは抗酸菌の細胞壁のペプチドグルカンとアラビノガラクタンとの結合点の構造［→４） ‐α‐L‐Rha‐(１→３)‐α‐D‐GlcNAc‐(１→］を構成する鍵になる化合物...
Предложен новый способ синтеза труднодоступных и стерически затрудненных N,N-диалкоксикарбаматов и N...
The value of methyl 3-O-benzyl-2,6-dideoxy-2,6-imino-α-D-mannofuranoside as a divergent intermediate...
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