在阿尔茨海默病(AD)的病例中,散发型AD占很大部分,其主要临床特征是认知障碍.脂类及相关蛋白是造成散发型AD的重要危险因素之一.大量研究发现,胆固醇代谢、脂蛋白(a)、载脂蛋白ApoE等都与AD的发病和痴呆的发生有重要关联.国家自然科学基金; 国家重点基础研究发展计划(973计划)中国科技核心期刊(ISTIC)05329-334
International audienceBACKGROUND:There are now significant evidences that lipid metabolism is affect...
International audienceBACKGROUND:There are now significant evidences that lipid metabolism is affect...
International audienceBACKGROUND:There are now significant evidences that lipid metabolism is affect...
人类生长发育到成熟期以后,随着年龄的增长,机体在形态结构和生理功能方面必然会出现一系列的退行性变化,即髓鞘发育生成受损,神经细胞萎缩,细胞内脂褐素蓄积,细胞间突触联系和蕴藏的生化物质减少,接受和传递信...
载脂蛋白E(ApoE)基因作为阿尔茨海默病(AD)发生的基因危险因素,揭示了胆固醇代谢与AD密切关系.作为AD显著病理标志的β淀粉样肽(Aβ)的异常产生和沉积受胆固醇的调节.这种调节具有双向性.在AD...
WOS: 000253935100002PubMed ID: 18288926Advances in Alzheimer Disease (AD) research suggest that cent...
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAM...
载脂蛋白E (ApoE)基因型是现在所知的散发型和迟发型阿尔茨海默症的最大的危险因子,它是中枢神经系统中主要的胆固醇运载体,同时又是极低密度脂蛋白(VLDL)的组成成分.ApoE对脑内胆固醇代谢异常和...
目的 研究宁夏地区阿尔茨海默病(AD)和轻度认知功能障碍(MCI)与载脂蛋白E(ApoE)基因多态性的关系.方法 采用PCR-RFLP(限制性片段长度多态性)方法检测80例AD患者,80例MCI患者及...
Although Alzheimer’s disease (AD) causes massive and irreversible neurodegeneration, prevention and ...
载脂蛋白(Apolipoprotein,Apo)E存在于多种脂蛋白颗粒中,是正常人血浆脂蛋白中重要的载脂蛋白成分,主要功能为运输并介导某些脂蛋白与相应的受体.在神经系统中,ApoE参与胆固醇及磷脂的动...
International audienceBACKGROUND:There are now significant evidences that lipid metabolism is affect...
Alzheimer's disease is the principal cause of dementia throughout the world and the fourth cause of ...
INTRODUCTION: The aim of this study was to (1) replicate previous associations between six blood lip...
Alzheimer's disease is the principal cause of dementia throughout the world and the fourth cause of ...
International audienceBACKGROUND:There are now significant evidences that lipid metabolism is affect...
International audienceBACKGROUND:There are now significant evidences that lipid metabolism is affect...
International audienceBACKGROUND:There are now significant evidences that lipid metabolism is affect...
人类生长发育到成熟期以后,随着年龄的增长,机体在形态结构和生理功能方面必然会出现一系列的退行性变化,即髓鞘发育生成受损,神经细胞萎缩,细胞内脂褐素蓄积,细胞间突触联系和蕴藏的生化物质减少,接受和传递信...
载脂蛋白E(ApoE)基因作为阿尔茨海默病(AD)发生的基因危险因素,揭示了胆固醇代谢与AD密切关系.作为AD显著病理标志的β淀粉样肽(Aβ)的异常产生和沉积受胆固醇的调节.这种调节具有双向性.在AD...
WOS: 000253935100002PubMed ID: 18288926Advances in Alzheimer Disease (AD) research suggest that cent...
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAM...
载脂蛋白E (ApoE)基因型是现在所知的散发型和迟发型阿尔茨海默症的最大的危险因子,它是中枢神经系统中主要的胆固醇运载体,同时又是极低密度脂蛋白(VLDL)的组成成分.ApoE对脑内胆固醇代谢异常和...
目的 研究宁夏地区阿尔茨海默病(AD)和轻度认知功能障碍(MCI)与载脂蛋白E(ApoE)基因多态性的关系.方法 采用PCR-RFLP(限制性片段长度多态性)方法检测80例AD患者,80例MCI患者及...
Although Alzheimer’s disease (AD) causes massive and irreversible neurodegeneration, prevention and ...
载脂蛋白(Apolipoprotein,Apo)E存在于多种脂蛋白颗粒中,是正常人血浆脂蛋白中重要的载脂蛋白成分,主要功能为运输并介导某些脂蛋白与相应的受体.在神经系统中,ApoE参与胆固醇及磷脂的动...
International audienceBACKGROUND:There are now significant evidences that lipid metabolism is affect...
Alzheimer's disease is the principal cause of dementia throughout the world and the fourth cause of ...
INTRODUCTION: The aim of this study was to (1) replicate previous associations between six blood lip...
Alzheimer's disease is the principal cause of dementia throughout the world and the fourth cause of ...
International audienceBACKGROUND:There are now significant evidences that lipid metabolism is affect...
International audienceBACKGROUND:There are now significant evidences that lipid metabolism is affect...
International audienceBACKGROUND:There are now significant evidences that lipid metabolism is affect...
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