The Dynamic Coupling of Right Ventricle and Pulmonary Arteries

根据肺循环血管系统的解剖结构,提出了模拟肺动脉输入阻抗的轻微非对称T型管模型.计算得到的肺动脉输入阻抗与实验数据比较表明,该模型能很好地模拟右心室的后负荷.还利用右心室的E(t)-R模型及肺动脉的轻微非对称T型管模型,应用脉冲响应法,对肺循环的动态耦合及心血管参数的影响进行了研究,发现了一个心动周期中,右心室对肺动脉压力和流量变化起主导作用.Based on the anatomical structure of pulmonary arteries, a slightly asymmetric T-tube model with distributed parameters is proposed herein to simulate the pulmonary arteries. Comparison between our calculated input impedance to the pulmonary arteries with available experimental data proves that such a model provides an excellent simulation to the right ventricular afterload. With a E (t)-R model for the right ventricle and a slightly asymmetric T tube model for the pulmonary arteries, the dynamic coupling of the right ventricle and pulmonary circulation is quantitatively studied using the impulse response method. The influence of various cardiovascular parameters is discussed. It is found that the right ventricle plays a predominant role over the pulmonary arteries in determining the pulmonary blood pressure and flow variations during a cardiac cycle.国家自然科学基金中文核心期刊要目总览(PKU)中国科学引文数据库(CSCD)03317-3273