Preparation and physicochemical characterization of solid dispersion of quercetin and polyvinylpyrrolidone

目的 用溶剂法制备槲皮素-PVP固体分散体并考察其溶出特性并对物相进行鉴定.方法 采用溶剂法制备槲皮素-PVP固体分散体,通过溶出实验对槲皮素溶出率的测定研究固体分散体的溶出性质,利用差热分析(Differential scanning calorimetry,DSC)、红外光谱分析(Infrared spectroscopy,IR)、粉末X衍射(X-ray powder diffractometry,PXRD)、扫描电镜(Scanning electron microscopy,SEM)等方法对其进行物相鉴定.结果 槲皮素-PVP固体分散体的溶出速率相对其物理混合物有了明显的改善;溶解实验显示固体分散体中槲皮素的溶解度有了显著的提高;热差分析及粉末X衍射结果表明固体分散体中槲皮素呈非结晶形式;扫描电镜下固体分散体中无槲皮素晶体.结论 采用溶剂法制备槲皮素-PVP固体分散体可显著提高槲皮素的溶解度及溶出速度.Aim The objective of this study was to prepare and characterize quercetin-polyvinylpyrrolidone (Qurc-PVP)solid dispersion with the intention of improving its dissolution properties. Methods Qurc-PVP sclid dispersion was prepared by solvent method. The release rate of quercetin was determined from dissolution studies and the physicochemical properties of solid dispersion were investigated by differential scanning calorimetry (DSC), infrared spectroscopy (IR), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM). Results The results showed that the dissolution rate of quercetin was significantly improved by solid dispersion compared to that of the pure drug and physical mixture. Solubility studies revealed a markedly increase in the solubility of quercetin. The results of DSC and PXRD showed that the quercetin in solid dispersion was amorphous form. From SEM analysis, there was no quercetin crystal observed in the solid dispersions.Conclusion The solubility and dissolution of quercetin were improved by solid dispersion technique.0151-561