Summary: Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and disease. Thus far, it has proven difficult to develop successful treatment strategies for diseases that are caused by mtDNA instability. To address this issue, we developed a model of mtDNA disease in the nematode C. elegans, an animal model that can rapidly be screened for genes and biological pathways that reduce mitochondrial pathology. These worms recapitulate all the major hallmarks of mtDNA disease in humans, including increased mtDNA instability, loss of respiration, reduced neuromuscular function, and a shortened lifespan. We found that these phenotypes could be rescued by intervening in numerous biological pathways, including...
Mitochondria play a pivotal role in controlling cellular homeostasis. The mitochondrial respiratory ...
Mitochondria play a pivotal role in controlling cellular homeostasis. The mitochondrial respiratory ...
MSc (Biochemistry), North-West University, Potchefstroom CampusMutations in mitochondrial DNA (mtDNA...
Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and d...
Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and d...
Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and d...
Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and d...
Eukaryotic cells are divided into many compartments, enabling spatial and temporal regulation in hig...
Eukaryotic cells are divided into many compartments, enabling spatial and temporal regulation in hig...
Mitochondria play a pivotal role in controlling cellular homeostasis. The mitochondrial respiratory ...
Mitochondria play a pivotal role in controlling cellular homeostasis. The mitochondrial respiratory ...
Mitochondria play a pivotal role in the life of cells, controlling diverse processes ranging from en...
Mitochondria play a pivotal role in the life of cells, controlling diverse processes ranging from en...
Mitochondria play a pivotal role in the life of cells, controlling diverse processes ranging from en...
Mitochondria play a pivotal role in controlling cellular homeostasis. The mitochondrial respiratory ...
Mitochondria play a pivotal role in controlling cellular homeostasis. The mitochondrial respiratory ...
Mitochondria play a pivotal role in controlling cellular homeostasis. The mitochondrial respiratory ...
MSc (Biochemistry), North-West University, Potchefstroom CampusMutations in mitochondrial DNA (mtDNA...
Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and d...
Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and d...
Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and d...
Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and d...
Eukaryotic cells are divided into many compartments, enabling spatial and temporal regulation in hig...
Eukaryotic cells are divided into many compartments, enabling spatial and temporal regulation in hig...
Mitochondria play a pivotal role in controlling cellular homeostasis. The mitochondrial respiratory ...
Mitochondria play a pivotal role in controlling cellular homeostasis. The mitochondrial respiratory ...
Mitochondria play a pivotal role in the life of cells, controlling diverse processes ranging from en...
Mitochondria play a pivotal role in the life of cells, controlling diverse processes ranging from en...
Mitochondria play a pivotal role in the life of cells, controlling diverse processes ranging from en...
Mitochondria play a pivotal role in controlling cellular homeostasis. The mitochondrial respiratory ...
Mitochondria play a pivotal role in controlling cellular homeostasis. The mitochondrial respiratory ...
Mitochondria play a pivotal role in controlling cellular homeostasis. The mitochondrial respiratory ...
MSc (Biochemistry), North-West University, Potchefstroom CampusMutations in mitochondrial DNA (mtDNA...