Filaggrin (‘filament-aggregating protein’) plays an essential role in the terminal differentiation of the epidermis. It forms an important barrier function of the skin preventing transepidermal water loss and penetration of allergens into the skin. The human profilaggrin gene consists of three exons, located on chromosome 1q21. At present, 85 unique filaggrin mutations are described in the literature. Especially the West-European and Asian population have been subject to investigation. There is a clear distinction in the spectrum of filaggrin mutations between different ethnic populations. Therefore knowledge of a patient’s ancestry is very important for genetic testing. Homozygote and compound heterozygote mutations cause a relatively seve...
Mutations in the filament aggregating protein (filaggrin) gene have recently been identified as the ...
Background Ichthyosis vulgaris (IV) is a genetic disorder with a prevalence of 1 : 250- 1000 caused ...
Ichthyosis vulgaris (OMIM 146700) is the most common inherited disorder of keratinization and one of...
Filaggrin (‘filament-aggregating protein’) plays an essentialrole in the terminal differentiation of...
NOTE: THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REF...
Filaggrin is an abundant protein of the outer epidermis that is essential for terminal differentiati...
ABSTRACTFilaggrin is a key protein that facilitates terminal differentiation of the epidermis and fo...
Filaggrin is an abundant protein of the outer epidermis that is essential for terminal differentiati...
Filaggrin is a key protein involved in skin barrier function. Recently, mutations in the filaggrin g...
Mutations in the filament aggregating protein (filaggrin) gene have recently been identified as the ...
Background Ichthyosis vulgaris (IV) is a genetic disorder with a prevalence of 1 : 250- 1000 caused ...
Ichthyosis vulgaris (OMIM 146700) is the most common inherited disorder of keratinization and one of...
Filaggrin (‘filament-aggregating protein’) plays an essentialrole in the terminal differentiation of...
NOTE: THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REF...
Filaggrin is an abundant protein of the outer epidermis that is essential for terminal differentiati...
ABSTRACTFilaggrin is a key protein that facilitates terminal differentiation of the epidermis and fo...
Filaggrin is an abundant protein of the outer epidermis that is essential for terminal differentiati...
Filaggrin is a key protein involved in skin barrier function. Recently, mutations in the filaggrin g...
Mutations in the filament aggregating protein (filaggrin) gene have recently been identified as the ...
Background Ichthyosis vulgaris (IV) is a genetic disorder with a prevalence of 1 : 250- 1000 caused ...
Ichthyosis vulgaris (OMIM 146700) is the most common inherited disorder of keratinization and one of...