Unnatural history of tetralogy of Fallot: prospective follow-up of 40 years after surgical correction
- Cuypers, Judith A. A. E.
- Menting, Myrthe E.
- Konings, Elisabeth E. M.
- Opić, Petra
- Utens, Elisabeth M. W. J.
- Helbing, Willem A.
- Witsenburg, Maarten
- van den Bosch, Annemien E.
- Ouhlous, Mohamed
- van Domburg, Ron T.
- Rizopoulos, Dimitris
- Meijboom, Folkert J.
- Boersma, Eric
- Bogers, Ad J. J. C.
- Roos-Hesselink, Jolien W.
DOIAbstract
Prospective data on long-term survival and clinical outcome beyond 30 years after surgical correction of tetralogy of Fallot are nonexistent. This longitudinal cohort study consists of the 144 patients with tetralogy of Fallot who underwent surgical repair at <15 years of age between 1968 and 1980 in our center. They are investigated every 10 years. Cumulative survival (data available for 136 patients) was 72% after 40 years. Late mortality was due to heart failure and ventricular fibrillation. Seventy-two of 80 eligible survivors (90%) participated in the third in-hospital investigation, consisting of ECG, Holter, echocardiography, cardiopulmonary exercise testing, N-terminal pro-brain natriuretic peptide measurement, cardiac magnetic reso...
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