PURPOSE: Magnetic resonance imaging (MRI) with targeted contrast agents provides a promising means for diagnosis and treatment monitoring after cerebrovascular injury. Our goal was to demonstrate the feasibility of this approach to detect the neuroinflammatory biomarker intercellular adhesion molecule-1 (ICAM-1) after stroke and to establish a most efficient imaging procedure. PROCEDURES: We compared two types of ICAM-1-functionalized contrast agent: T 1-shortening gadolinium chelate-containing liposomes and T2(*)-shortening micron-sized iron oxide particles (MPIO). Binding efficacy and MRI contrast effects were tested in cell cultures and a mouse stroke model. RESULTS: Both ICAM-1-targeted agents bound effectively to activated cerebrovascu...
OBJECTIVE: Identification of patients with high-risk asymptomatic carotid plaques remains an elusive...
Molecular magnetic resonance imaging (MRI) allows visualization of biological processes at the molec...
Purpose: A major issue for the effective treatment of brain metastasis is the late stage of diagnosi...
Item does not contain fulltextPURPOSE: Magnetic resonance imaging (MRI) with targeted contrast agent...
Magnetic resonance imaging (MRI) with targeted contrast agents provides a promising means for diagno...
Molecular MRI allows in vivo detection of vascular cell adhesion molecules expressed on inflamed end...
ABSTRACT: BACKGROUND: The upregulation of intercellular adhesion molecule-1 (ICAM-1) on the endothel...
This thesis describes the use of different MR contrast agent platforms for the direct detection of p...
Multiple sclerosis is a disease of the central nervous system that is associated with leukocyte recr...
OBJECTIVE: Identification of patients with high-risk asymptomatic carotid plaques remains an elusive...
Contrast agents are widely used with magnetic resonance imaging (MRI) to increase the contrast betwe...
MRI is an increasingly important clinical tool, but it is clear that conventional imaging fails to i...
MRI is an increasingly important clinical tool, but it is clear that conventional imaging fails to i...
Purpose: A major issue for the effective treatment of brain metastasis is the late stage of diagnosi...
Background: Molecular MRI is an evolving field of research with strong translational potential. Sele...
OBJECTIVE: Identification of patients with high-risk asymptomatic carotid plaques remains an elusive...
Molecular magnetic resonance imaging (MRI) allows visualization of biological processes at the molec...
Purpose: A major issue for the effective treatment of brain metastasis is the late stage of diagnosi...
Item does not contain fulltextPURPOSE: Magnetic resonance imaging (MRI) with targeted contrast agent...
Magnetic resonance imaging (MRI) with targeted contrast agents provides a promising means for diagno...
Molecular MRI allows in vivo detection of vascular cell adhesion molecules expressed on inflamed end...
ABSTRACT: BACKGROUND: The upregulation of intercellular adhesion molecule-1 (ICAM-1) on the endothel...
This thesis describes the use of different MR contrast agent platforms for the direct detection of p...
Multiple sclerosis is a disease of the central nervous system that is associated with leukocyte recr...
OBJECTIVE: Identification of patients with high-risk asymptomatic carotid plaques remains an elusive...
Contrast agents are widely used with magnetic resonance imaging (MRI) to increase the contrast betwe...
MRI is an increasingly important clinical tool, but it is clear that conventional imaging fails to i...
MRI is an increasingly important clinical tool, but it is clear that conventional imaging fails to i...
Purpose: A major issue for the effective treatment of brain metastasis is the late stage of diagnosi...
Background: Molecular MRI is an evolving field of research with strong translational potential. Sele...
OBJECTIVE: Identification of patients with high-risk asymptomatic carotid plaques remains an elusive...
Molecular magnetic resonance imaging (MRI) allows visualization of biological processes at the molec...
Purpose: A major issue for the effective treatment of brain metastasis is the late stage of diagnosi...