Is there a relationship between human cortical bone toughness and collagen enzymatic cross-links?

22nd Congress of the European Society of Biomechanics, SEVILLE, ESPAGNE, 10-/07/2017 - 13/07/2017A recent study showed that human cortical bone fracture toughness is higher at the radial diaphysis compared to the femoral diaphysis or femoral neck when loaded under quasi-static rate. Radius seems to be able to undergo more plastic mechanisms that slow down crack propagation. It has also been shown that the ratio between mature and immature enzymatic crosslinks (called CX) may have an influence on the non-linear behavior of human cortical bone. The aim of this study is to investigate the relationships between toughness and the ratio CX of human cortical bones