Genomic and epigenetic alterations are now being exploited as molecular targets in cancer treatment. Abnormalities involving the post-translational modification of histones have been demonstrated in thyroid cancer, and they are regarded as promising molecular targets for novel drug treatment of tumors that are resistant to conventional therapies. After a brief overview of the histone modifications most commonly associated with human malignancies, we will review recently published preclinical and clinical findings regarding the use of histone-activity modulators in thyroid cancers. Particular attention will be focused on their use as re-differentiating or anti-proliferating agents, the differential effects observed when they are used alone a...
Thyroid cancer is the most common endocrine malignancy. Recent developments in molecular biological ...
Alteration of the chromatin orchestra seems to play a critical role in cancer. In recent years, in-d...
Hematologic malignancies are a large and heterogeneous group of neoplasms characterized by complex p...
An increasing body of evidence suggests that epigenetic changes (DNA methylation, remodeling and pos...
Introduction: Epigenetic changes have been detected in thyroid cancer cells, and evidence indicates ...
Abstract Post-translational methylation of histone lysine or arginine residues plays important roles...
Thyroid cancer is a common diagnosis with greater than 34,000 cases per year in the United States. E...
Among the most promising new antineoplastic therapies for poorly differentiated or undifferentiated ...
Background: Medullary thyroid carcinoma (MTC) originates from the parafollicular C cells of the thyr...
Thyroid cancer remains the most common malignancy of the endocrine system worldwide. The indicators ...
Involvement of epigenetic modifications in cancers: development of new therapeutic approaches. Since...
BACKGROUND:We evaluated the therapeutic effects of the histone deacetylase inhibitor PXD101 alone an...
Histone proteins are subject to a diverse range of post-translational modifications which, along wit...
Histone proteins are subject to a diverse range of post-translational modifications which, along wit...
Background: We evaluated the therapeutic effects of the histone deacetylase inhibitor PXD101 alone a...
Thyroid cancer is the most common endocrine malignancy. Recent developments in molecular biological ...
Alteration of the chromatin orchestra seems to play a critical role in cancer. In recent years, in-d...
Hematologic malignancies are a large and heterogeneous group of neoplasms characterized by complex p...
An increasing body of evidence suggests that epigenetic changes (DNA methylation, remodeling and pos...
Introduction: Epigenetic changes have been detected in thyroid cancer cells, and evidence indicates ...
Abstract Post-translational methylation of histone lysine or arginine residues plays important roles...
Thyroid cancer is a common diagnosis with greater than 34,000 cases per year in the United States. E...
Among the most promising new antineoplastic therapies for poorly differentiated or undifferentiated ...
Background: Medullary thyroid carcinoma (MTC) originates from the parafollicular C cells of the thyr...
Thyroid cancer remains the most common malignancy of the endocrine system worldwide. The indicators ...
Involvement of epigenetic modifications in cancers: development of new therapeutic approaches. Since...
BACKGROUND:We evaluated the therapeutic effects of the histone deacetylase inhibitor PXD101 alone an...
Histone proteins are subject to a diverse range of post-translational modifications which, along wit...
Histone proteins are subject to a diverse range of post-translational modifications which, along wit...
Background: We evaluated the therapeutic effects of the histone deacetylase inhibitor PXD101 alone a...
Thyroid cancer is the most common endocrine malignancy. Recent developments in molecular biological ...
Alteration of the chromatin orchestra seems to play a critical role in cancer. In recent years, in-d...
Hematologic malignancies are a large and heterogeneous group of neoplasms characterized by complex p...