Faktor Prognostik dan Kesintasan Pasien Leukemia Limfoblastik Akut Anak di RSUP Dr. Sardjito, YOGYAKARTA, 2010–2015

Acute lymphoblastic leukemia (ALL) is the most common hematologic Malignancy in children. Improvements in ALL management in developed countries have shown that the survival rate can be up to 90%. This achievement may be attributed to the stratification of therapy based on prognostic factors. This study aims to evaluate the survival rate of childhood ALL at Sardjito Hospital and prognostic factors for survival. Newly diagnosed patients with ALL aged less than 18 years from January 2010 - December 2015 were enrolled. Patients who have previously received chemotherapy, those with ALL type L3, and those with mixed leukemia were excluded. The survival rate was analyzed by Kaplan-Meier method using log-rank test. Cox regression analysis was used to identify prognostic factors. A total of 309 patients were analyzed. The survival rate of childhood LLA in 2010-2015 in Sardjito Hospital was 56.1 ± 3.9%. Risk grouping based on National Cancer Institute is a prognostic factor that influences the survival of childhood LLA