Different Plasma Markers of Inflammation Are Influenced by Immune Recovery and cART Composition or Intensification in Treated HIV Infected Individuals
- Massanella, Marta
- Ouchi, Dan
- Marfil, Silvia
- Llibre, Josep María
- Puertas, Maria C.
- Buzón, María J.
- Richman, Douglas D.
- Orna, Elisa
- Stevenson, Mario
- Gatell, José M.
- Domingo, Pere (Domingo Pedrol)
- Negredo, Eugènia
- Martínez Picado, Francisco Javier
- Clotet i Sala, Bonaventura
- Blanco, Julià
DOIAbstract
BACKGROUND: HIV-1 infection increases plasma levels of inflammatory markers. Combination antiretroviral therapy (cART) does not restore inflammatory markers to normal levels. Since intensification of cART with raltegravir reduced CD8 T-cell activation in the Discor-Ral and IntegRal studies, we have evaluated the effect of raltegravir intensification on several soluble inflammation markers in these studies. METHODS: Longitudinal plasma samples (0-48 weeks) from the IntegRal (n = 67, 22 control and 45 intensified individuals) and the Discor-Ral studies (44 individuals with CD4 T-cell counts<350 cells/µl, 14 control and 30 intensified) were assayed for 25 markers. Mann-Whitney, Wilcoxon, Spearman test and linear mixed models were used for anal...
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