Although c-Myc is essential for melanocyte development, its role in cutaneous melanoma, the most aggressive skin cancer, is only partly understood. Here we used the <i>Nras</i> <sup> <i>Q61K</i> </sup> <i>INK4a</i> <sup>-/-</sup> mouse melanoma model to show that c-Myc is essential for tumor initiation, maintenance, and metastasis. c-Myc-expressing melanoma cells were preferentially found at metastatic sites, correlated with increased tumor aggressiveness and high tumor initiation potential. Abrogation of c-Myc caused apoptosis in primary murine and human melanoma cells. Mechanistically, c-Myc-positive melanoma cells activated and bec...
Abstract Background AMP-activated protein kinase (AMPK) is a metabolic sensor that maintains energy ...
Cancer progression is a multi-step process requiring cells to acquire specific properties that aid t...
Targeted inhibitors of oncogenic Ras (rat sarcoma viral oncogene)-Raf signaling have shown great pro...
Although c-Myc is essential for melanocyte development, its role in cutaneous melanoma, the most agg...
Raf/MEK/ERK signaling can inhibit the liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) pathw...
<p>(A) UACC903, A375 and SKMel28 human melanoma cells were grown in complete medium (H.G.), or low g...
AMP-activated protein kinase (AMPK) is a highly conserved serine-threonine protein kinase which acts...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Rapidly growing tumor cells outgrow their blood supply resulting in a microenvironment with reduced ...
Aim: The Mitogen-Activated Protein Kinase (MAPK) pathway and the AKT pathway regulate cell growth, s...
Background: Understanding the biochemical mechanisms contributing to melanoma development and progre...
Clinical management of melanomas with NRAS mutations is challenging. Targeting MAPK signaling is onl...
MYC is a transcription factor and a proto-oncogene, which is overexpressed in almost 50% of all brea...
International audienceThe microphthalmia-associated transcription factor (MITF) is indispensable for...
Cutaneous malignant melanoma is an aggressive form of skin cancer, characterized by strong chemoresi...
Abstract Background AMP-activated protein kinase (AMPK) is a metabolic sensor that maintains energy ...
Cancer progression is a multi-step process requiring cells to acquire specific properties that aid t...
Targeted inhibitors of oncogenic Ras (rat sarcoma viral oncogene)-Raf signaling have shown great pro...
Although c-Myc is essential for melanocyte development, its role in cutaneous melanoma, the most agg...
Raf/MEK/ERK signaling can inhibit the liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) pathw...
<p>(A) UACC903, A375 and SKMel28 human melanoma cells were grown in complete medium (H.G.), or low g...
AMP-activated protein kinase (AMPK) is a highly conserved serine-threonine protein kinase which acts...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Rapidly growing tumor cells outgrow their blood supply resulting in a microenvironment with reduced ...
Aim: The Mitogen-Activated Protein Kinase (MAPK) pathway and the AKT pathway regulate cell growth, s...
Background: Understanding the biochemical mechanisms contributing to melanoma development and progre...
Clinical management of melanomas with NRAS mutations is challenging. Targeting MAPK signaling is onl...
MYC is a transcription factor and a proto-oncogene, which is overexpressed in almost 50% of all brea...
International audienceThe microphthalmia-associated transcription factor (MITF) is indispensable for...
Cutaneous malignant melanoma is an aggressive form of skin cancer, characterized by strong chemoresi...
Abstract Background AMP-activated protein kinase (AMPK) is a metabolic sensor that maintains energy ...
Cancer progression is a multi-step process requiring cells to acquire specific properties that aid t...
Targeted inhibitors of oncogenic Ras (rat sarcoma viral oncogene)-Raf signaling have shown great pro...