Personality Polygenes, Positive Affect, and Life Satisfaction
- Weiss, Alexander
- Baselmans, Bart M. L.
- Hofer, Edith
- Yang, Jingyun
- Okbay, Aysu
- Lind, Penelope A.
- Miller, Mike B.
- Nolte, Ilja M.
- Zhao, Wei
- Hagenaars, Saskia P.
- Hottenga, Jouke-Jan
- Matteson, Lindsay K.
- Snieder, Harold
- Faul, Jessica D.
- Hartman, Catharina A.
- Boyle, Patricia A.
- Tiemeier, Henning
- Mosing, Miriam A.
- Pattie, Alison
- Davies, Gail
- Liewald, David C.
- Schmidt, Reinhold
- De Jager, Philip L.
- Heath, Andrew C.
- Jokela, Markus
- Starr, John M.
- Oldehinkel, Albertine J.
- Johannesson, Magnus
- Cesarini, David
- Hofman, Albert
- Harris, Sarah E.
- Smith, Jennifer A.
- Keltikangas-Järvinen, Liisa
- Pulkki-Råback, Laura
- Schmidt, Helena
- Smith, Jacqui
- Iacono, William G.
- McGue, Matt
- Bennett, David A.
- Pedersen, Nancy L.
- Magnusson, Patrik K. E.
- Deary, Ian J.
- Martin, Nicholas G.
- Boomsma, Dorret I.
- Bartels, Meike
- Luciano, Michelle
DOIAbstract
Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general we...
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