Free Water Imaging is a novel diffusion magnetic reasonance imaging (MRI) method that is able to separate changes affecting the extracellular space from those that reflect changes in neuronal cells and processes. A previous Free Water Imaging study in schizophrenia identified significantly greater extracellular water volume in the early stages of the disorder; however, it’s clinical and functional sequelae have not yet been investigated. Here, we applied Free Water Imaging to a larger cohort of 63 first-episode patients with psychosis and 70 healthy matched controls to better understand the functional significance of greater extracellular water. We used diffusion MRI data and the Tract-Based Spatial Statistics analytic pipeline to first ana...
The development of diffusion tensor imaging (DTI) has provided information about microstructural cha...
Background/Aims: Previous diffusion tensor imaging (DTI) studies have shown microstructural changes ...
Background: While many diffusion tensor imaging (DTI) investigations have noted disruptions to white...
Free Water Imaging is a novel diffusion magnetic resonance (MR) imaging method that is able to separ...
Recent diffusion imaging studies using free-water (FW) elimination have shown increased FW in gray m...
Studies applying Free Water Imaging have consistently reported significant global increases in extra...
BackgroundMultiple lines of evidence suggest the presence of altered neuroimmune processes in patien...
Diffusion tensor imaging (DTI) studies in chronic schizophrenia have found widespread but often inco...
Evidence has been accumulating for an immune-based component to the etiology of psychotic disorders....
Diffusion weighted imaging (DWI) has been extensively used to study the microarchitecture of white m...
INTRODUCTION: Clarifying the role of neuroinflammation in schizophrenia is subject to its detection ...
Background: Studies in individuals at clinical high risk (CHR) for psychosis provide a powerful mean...
Various lines of research suggest immune dysregulation as a potential therapeutic target for negativ...
Schizophrenia is a severe mental disorder with often a chronic course. Neuroimaging studies report b...
Background: Diffusion tensor imaging suggests that white matter alterations are already evident in f...
The development of diffusion tensor imaging (DTI) has provided information about microstructural cha...
Background/Aims: Previous diffusion tensor imaging (DTI) studies have shown microstructural changes ...
Background: While many diffusion tensor imaging (DTI) investigations have noted disruptions to white...
Free Water Imaging is a novel diffusion magnetic resonance (MR) imaging method that is able to separ...
Recent diffusion imaging studies using free-water (FW) elimination have shown increased FW in gray m...
Studies applying Free Water Imaging have consistently reported significant global increases in extra...
BackgroundMultiple lines of evidence suggest the presence of altered neuroimmune processes in patien...
Diffusion tensor imaging (DTI) studies in chronic schizophrenia have found widespread but often inco...
Evidence has been accumulating for an immune-based component to the etiology of psychotic disorders....
Diffusion weighted imaging (DWI) has been extensively used to study the microarchitecture of white m...
INTRODUCTION: Clarifying the role of neuroinflammation in schizophrenia is subject to its detection ...
Background: Studies in individuals at clinical high risk (CHR) for psychosis provide a powerful mean...
Various lines of research suggest immune dysregulation as a potential therapeutic target for negativ...
Schizophrenia is a severe mental disorder with often a chronic course. Neuroimaging studies report b...
Background: Diffusion tensor imaging suggests that white matter alterations are already evident in f...
The development of diffusion tensor imaging (DTI) has provided information about microstructural cha...
Background/Aims: Previous diffusion tensor imaging (DTI) studies have shown microstructural changes ...
Background: While many diffusion tensor imaging (DTI) investigations have noted disruptions to white...