Altered lipid metabolism and extensive lipid storage in cells have been associated with various medical disorders, including cancer. The development of fluorescent probes that specifically accumulate in lipid deposits is therefore of great interest in order to study pathological processes that are linked to dysregulated lipogenesis. In the present study, we present a small fluorescent benzothiadiazole dye that specifically stains lipid droplets in living and fixated cells. The photophysical characterization of the probe revealed strong solvatochromic behavior, large Stokes shifts, and high fluorescent quantum yields in hydrophobic solvents. In addition, the fluorophore exhibits a nontoxic profile and a high signal-to-noise ratio in cells (i...
Intracellular lipid storage and regulation occur in lipid droplets, which are of great significance ...
Molecular tools for fluorescent imaging of specific compartments in cells are essential for understa...
We present a highly fluorescent, solvatochromic, 1,8-naphthalimide for simultaneous imaging of lipid...
Altered lipid metabolism and extensive lipid storage in cells have been associated with various medi...
International audienceIn this study we describe the development of new lipophilic and biocompatible ...
A robust lipophilic dye, based on the structures of the benzothiadiazole heterocycle, was shown to b...
Intracellular lipid metabolism occurs in lipid droplets (LDs), which is critical to the survival of ...
In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various N-substituents...
Lipid droplets (LDs) are simple intracellular storage sites for neutral lipids and exhibit important...
A lipophilic dye based on the Bodipy fluorophore, LD540, was developed for microscopic imaging of li...
We present an extensive photophysical study of a series of fluorescent indolylbenzothiadiazole deriv...
Cell membranes are believed to be laterally ordered into micro and nano-domains comprising of more f...
Lipid droplets (LDs) are organelles that serve as the storage of intracellular neutral lipids. LDs r...
We evaluated a number of lipophilic dyes and fluorochromes, including oxazone and thiazone derivativ...
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Lipid droplets (LDs) have been recognized as highl...
Intracellular lipid storage and regulation occur in lipid droplets, which are of great significance ...
Molecular tools for fluorescent imaging of specific compartments in cells are essential for understa...
We present a highly fluorescent, solvatochromic, 1,8-naphthalimide for simultaneous imaging of lipid...
Altered lipid metabolism and extensive lipid storage in cells have been associated with various medi...
International audienceIn this study we describe the development of new lipophilic and biocompatible ...
A robust lipophilic dye, based on the structures of the benzothiadiazole heterocycle, was shown to b...
Intracellular lipid metabolism occurs in lipid droplets (LDs), which is critical to the survival of ...
In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various N-substituents...
Lipid droplets (LDs) are simple intracellular storage sites for neutral lipids and exhibit important...
A lipophilic dye based on the Bodipy fluorophore, LD540, was developed for microscopic imaging of li...
We present an extensive photophysical study of a series of fluorescent indolylbenzothiadiazole deriv...
Cell membranes are believed to be laterally ordered into micro and nano-domains comprising of more f...
Lipid droplets (LDs) are organelles that serve as the storage of intracellular neutral lipids. LDs r...
We evaluated a number of lipophilic dyes and fluorochromes, including oxazone and thiazone derivativ...
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Lipid droplets (LDs) have been recognized as highl...
Intracellular lipid storage and regulation occur in lipid droplets, which are of great significance ...
Molecular tools for fluorescent imaging of specific compartments in cells are essential for understa...
We present a highly fluorescent, solvatochromic, 1,8-naphthalimide for simultaneous imaging of lipid...