Radiogenomics of clear cell renal cell carcinoma: preliminary findings of The Cancer Genome Atlas–Renal Cell Carcinoma (TCGA–RCC) Imaging Research Group
- Shinagare, Atul
- Vikram, Raghu
- Jaffe, Carl
- Akin, Oguz
- Kirby, Justin
- Huang, Erich
- Freymann, John
- Sainani, Nisha I.
- Sadow, Cheryl Ann
- Bathala, Tharakeswara K.
- Rubin, Daniel Brett
- Oto, Aytekin
- Heller, Matthew T.
- Surabhi, Venkateswar R.
- Katabathina, Venkat
- Silverman, Stuart George
DOIAbstract
Purpose: To investigate associations between imaging features and mutational status of clear cell renal cell carcinoma (ccRCC). Materials and methods: This multi-institutional, multi-reader study included 103 patients (77 men; median age 59 years, range 34–79) with ccRCC examined with CT in 81 patients, MRI in 19, and both CT and MRI in three; images were downloaded from The Cancer Imaging Archive, an NCI-funded project for genome-mapping and analyses. Imaging features [size (mm), margin (well-defined or ill-defined), composition (solid or cystic), necrosis (for solid tumors: 0%, 1%–33%, 34%–66% or >66%), growth pattern (endophytic, <50% exophytic, or ≥50% exophytic), and calcification (present, absent, or indeterminate)] were reviewed inde...
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