Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform
- Gianella, Anita
- Mieszawska, Aneta J.
- Hoeben, Freek J. M.
- Janssen, Henk M.
- Jarzyna, Peter A.
- Cormode, David P.
- Costa, Kevin D.
- Rao, Satish
- Farokhzad, Omid Cameron
- Langer, Robert S.
- Fayad, Zahi A.
- Mulder, Willem J. M.
Publication date
October 2016
DOI Publisher
Royal Society of Chemistry (RSC) Journal
Chemical CommunicationsAbstract
We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using the biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles
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