Genes encoded close to one another on the chromosome are often coexpressed, by a mechanism and regulatory logic that remain poorly understood. We surveyed the yeast genome for tandem gene pairs oriented tail-to-head at which expression antisense to the upstream gene was conserved across species. The intergenic region at most such tandem pairs is a bidirectional promoter, shared by the downstream gene mRNA and the upstream antisense transcript. Genomic analyses of these intergenic loci revealed distinctive patterns of transcription factor regulation. Mutation of a given transcription factor verified its role as a regulator in trans of tandem gene pair loci, including the proximally initiating upstream antisense transcript and downstream mRNA...
Transcription plays a key role in cellular processes and its regulation is of paramount importance. ...
Recent transcription profiling studies have revealed an unexpectedly large proportion of antisense t...
AbstractIn budding yeast, approximately a quarter of adjacent genes are divergently transcribed (div...
Genes encoded close to one another on the chromosome are often coexpressed, by a mechanism and regul...
Transcription of RNA antisense to protein-coding genes is widespread in genomes from bacteria to hum...
Genome-wide transcription profiling has revealed extensive expression of non-coding RNAs antisense t...
Transcription lies at the centre of gene expression. In eukaryotes, transcription occurs not only at...
Background Recent studies in budding yeast have shown that antisense transcription occurs at many...
The relative positions that genes occupy on their respective chromosomes can play a critical role in...
<div><p>Paired sense and antisense (S/AS) genes located in <i>cis</i> represent a structural feature...
Paired sense and antisense (S/AS) genes located in cis represent a structural feature common to the ...
ABSTRACT It is essential that cells orchestrate gene expression for the specific niche that they occ...
ABSTRACT Balancing gene expression is a fundamental challenge of all cell types. To properly regulat...
The compressed nature of genes in yeast requires that transcription units be well defined to prevent...
Great strides have been made in understanding the evolution of gene regulation by focusing on the bu...
Transcription plays a key role in cellular processes and its regulation is of paramount importance. ...
Recent transcription profiling studies have revealed an unexpectedly large proportion of antisense t...
AbstractIn budding yeast, approximately a quarter of adjacent genes are divergently transcribed (div...
Genes encoded close to one another on the chromosome are often coexpressed, by a mechanism and regul...
Transcription of RNA antisense to protein-coding genes is widespread in genomes from bacteria to hum...
Genome-wide transcription profiling has revealed extensive expression of non-coding RNAs antisense t...
Transcription lies at the centre of gene expression. In eukaryotes, transcription occurs not only at...
Background Recent studies in budding yeast have shown that antisense transcription occurs at many...
The relative positions that genes occupy on their respective chromosomes can play a critical role in...
<div><p>Paired sense and antisense (S/AS) genes located in <i>cis</i> represent a structural feature...
Paired sense and antisense (S/AS) genes located in cis represent a structural feature common to the ...
ABSTRACT It is essential that cells orchestrate gene expression for the specific niche that they occ...
ABSTRACT Balancing gene expression is a fundamental challenge of all cell types. To properly regulat...
The compressed nature of genes in yeast requires that transcription units be well defined to prevent...
Great strides have been made in understanding the evolution of gene regulation by focusing on the bu...
Transcription plays a key role in cellular processes and its regulation is of paramount importance. ...
Recent transcription profiling studies have revealed an unexpectedly large proportion of antisense t...
AbstractIn budding yeast, approximately a quarter of adjacent genes are divergently transcribed (div...