A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN
- Jun, Gyungah
- Ibrahim-Verbaas, Carla A.
- Vronskaya, Maria
- Lambert, Jean-Charles
- Chung, Jaeyoon
- Naj, Adam C.
- Kunkle, Brian W.
- Wang, Li-San
- Bis, Joshua C.
- Bellenguez, Céline
- Harold, Denise
- Lunetta, Kathryn L.
- Destefano, Anita L.
- Grenier-Boley, Benjamin
- Sims, Rebecca
- Beecham, Gary W.
- Smith, Albert V.
- Chouraki, Vincent
- Hamilton-Nelson, Kara L.
- Ikram, M. Arfan
- Fievet, Nathalie
- Denning, Nicola
- Martin, Eden R.
- Schmidt, Helena
- Kamatani, Yochiro
- Dunstan, Melanie L
- Valladares, Otto
- Laza, Agustin Ruiz
- Zelenika, Diana
- Ramirez, Alfredo
- Foroud, Tatiana M.
- Choi, Seung-Hoan
- Boland, Anne
- Becker, Tim
- Kukull, Walter A.
- van der Lee, Sven J.
- Pasquier, Florence
- Cruchaga, Carlos
- Beekly, Duane
- Fitzpatrick, Annette L.
- Hanon, Oliver
- Gill, Michael
- Barber, Robert
- Gudnason, Vilmundur
- Campion, Dominique
- Love, Seth
- Bennett, David A.
- Amin, Najaf
- Berr, Claudine
- Tsolaki, Magda
- Buxbaum, Joseph D.
- Lopez, Oscar L.
- Deramecourt, Vincent
- Fox, Nick C
- Cantwell, Laura B.
- Tárraga, Lluis
- Dufouil, Carole
- Hardy, John
- Crane, Paul K.
- Eiriksdottir, Gudny
- Hannequin, Didier
- Clarke, Robert
- Evans, Denis
- Mosley, Thomas H.
- Letenneur, Luc
- Brayne, Carol
- Maier, Wolfgang
- De Jager, Philip
- Emilsson, Valur
- Dartigues, Jean-François
- Hampel, Harald
- Kamboh, M. Ilyas
- de Bruijn, Renee F.A.G.
- Tzourio, Christophe
- Pastor, Pau
- Larson, Eric B.
- Rotter, Jerome I.
- O’Donovan, Michael C
- Montine, Thomas J.
- Nalls, Michael A.
- Mead, Simon
- Reiman, Eric M.
- Jonsson, Palmi V.
- Holmes, Clive
- St George-Hyslop, Peter H.
- Boada, Mercè
- Passmore, Peter
- Wendland, Jens R.
- Schmidt, Reinhold
- Morgan, Kevin
- Winslow, Ashley R.
- Powell, John F
- Carasquillo, Minerva
- Younkin, Steven G.
- Jakobsdóttir, Jóhanna
- Kauwe, John SK
- Wilhelmsen, Kirk C.
- Rujescu, Dan
- Nöthen, Markus M
- Hofman, Albert
- Jones, Lesley
- Haines, Jonathan L.
- Psaty, Bruce M.
- Van Broeckhoven, Christine
- Holmans, Peter
- Launer, Lenore J.
- Mayeux, Richard
- Lathrop, Mark
- Goate, Alison M.
- Escott-Price, Valentina
- Seshadri, Sudha
- Pericak-Vance, Margaret A.
- Amouyel, Philippe
- Williams, Julie
- van Duijn, Cornelia M.
- Schellenberg, Gerard D.
- Farrer, Lindsay A.
DOIAbstract
APOE ε4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’s Project (IGAP) Consortium in APOE ε4+ (10,352 cases and 9,207 controls) and APOE ε4− (7,184 cases and 26,968 controls) subgroups as well as in the total sample testing for interaction between a SNP and APOE ε4 status. Suggestive associations (P<1x10−4) in stage 1 were evaluated in an independent sample (stage 2) containing 4,203 subjects (APOE ε4+: 1,250 cases and 536 controls; APOE ε4-: 718 cases and 1,699 controls). Among APOE ε4− subjects, novel genome-wide significant (GWS) association was observed with 17 SNPs (all between KA...
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