Accurate assessment of blood haemostasis is essential for the management of patients who use extracorporeal devices, receive anticoagulation therapy or experience coagulopathies. However, current monitoring devices do not measure effects of haemodynamic forces that contribute significantly to platelet function and thrombus formation. Here we describe a microfluidic device that mimics a network of stenosed arteriolar vessels, permitting evaluation of blood clotting within small sample volumes under pathophysiological flow. By applying a clotting time analysis based on a phenomenological mathematical model of thrombus formation, coagulation and platelet function can be accurately measured in vitro in patient blood samples. When the device is ...
Microfluidic devices and microsystems have been used to develop blood coagulation monitoring devices...
Microfluidic devices and microsystems have been used to develop blood coagulation monitoring devices...
Microfluidic devices and microsystems have been used to develop blood coagulation monitoring devices...
Current in vitro or ex vivo models of hemostasis and thrombosis fail to recapitulate the hemodynamic...
Diagnosis and monitoring of disorders of coagulation and disturbances in haemostasis has been around...
Hemostasis encompasses an ensemble of interactions among platelets, coagulation factors, blood cells...
Current in vitro or ex vivo models of hemostasis and thrombosis fail to recapitulate the hemodynamic...
Current in vitro or ex vivo models of hemostasis and thrombosis fail to recapitulate the hemodynamic...
The vascular endothelium and shear stress are critical determinants of physiological hemostasis and ...
Microfluidic models of hemostasis assess platelet function under conditions of hydrodynamic shear, b...
This paper provides an overview of the various types of microfluidic devices that are employed to st...
This paper provides an overview of the various types of microfluidic devices that are employed to st...
This paper provides an overview of the various types of microfluidic devices that are employed to st...
The simplicity and efficiency of point of care diagnostics have revolutionised patient care. Current...
The vascular endothelium and shear stress are critical determinants of physiological hemostasis and ...
Microfluidic devices and microsystems have been used to develop blood coagulation monitoring devices...
Microfluidic devices and microsystems have been used to develop blood coagulation monitoring devices...
Microfluidic devices and microsystems have been used to develop blood coagulation monitoring devices...
Current in vitro or ex vivo models of hemostasis and thrombosis fail to recapitulate the hemodynamic...
Diagnosis and monitoring of disorders of coagulation and disturbances in haemostasis has been around...
Hemostasis encompasses an ensemble of interactions among platelets, coagulation factors, blood cells...
Current in vitro or ex vivo models of hemostasis and thrombosis fail to recapitulate the hemodynamic...
Current in vitro or ex vivo models of hemostasis and thrombosis fail to recapitulate the hemodynamic...
The vascular endothelium and shear stress are critical determinants of physiological hemostasis and ...
Microfluidic models of hemostasis assess platelet function under conditions of hydrodynamic shear, b...
This paper provides an overview of the various types of microfluidic devices that are employed to st...
This paper provides an overview of the various types of microfluidic devices that are employed to st...
This paper provides an overview of the various types of microfluidic devices that are employed to st...
The simplicity and efficiency of point of care diagnostics have revolutionised patient care. Current...
The vascular endothelium and shear stress are critical determinants of physiological hemostasis and ...
Microfluidic devices and microsystems have been used to develop blood coagulation monitoring devices...
Microfluidic devices and microsystems have been used to develop blood coagulation monitoring devices...
Microfluidic devices and microsystems have been used to develop blood coagulation monitoring devices...