Body mass index and cognitive function: the potential for reverse causation

Background/Objective: Higher late life body mass index (BMI) is unrelated to or even predicts lower risk of dementia in late-life, a phenomenon that may be explained by reverse causation due to weight loss during pre-clinical phases of dementia. We aim to investigate the association of baseline BMI and changes in BMI with dementia in a large prospective cohort, and to examine whether weight loss predicts cognitive function. Methods: Using a national cohort of adults average age 58 at baseline in 1994 (n=7,029), we investigated the associations between baseline BMI in 1994 and memory scores from 2000 to 2010. We also examined the association of BMI change from 1994 to 1998 with memory scores from 2000 to 2010. Lastly, to investigate reverse causation, we examined whether memory scores in 1996 predicted BMI trajectories from 2000 to 2010. Results: Baseline overweight predicted better memory scores 6 to 16 years later (β=0.012, 95%CI=0.001; 0.023). Decline in BMI predicted lower memory scores over the subsequent 12 years (β= -0.026, 95%CI= -0.041; -0.011). Lower memory scores at mean age 60 in 1996 predicted faster annual rate of BMI decline during follow-up (β= -0.158 kg/m2 per year, 95% CI= -0.223;-0.094). Conclusion: Consistent with reverse causation, greater decline in BMI over the first four years of the study was associated with lower memory scores over the next decade and lower memory scores was associated with a decline in BMI. These findings suggest that pre-clinical dementia predicts weight loss for people as early as their late 50s