It has previously been shown in T cells that stimulation of protein kinase C (PKC) or the T cell antigen receptor (TCR) induces the rapid accumulation of the active guanosine triphosphate-bound form of p21ras. These stimuli also induce the activation of extracellular signal-regulated kinase 2 (ERK2), a serine/threonine kinase that is rapidly activated via a kinase c ascade in response to a variety of growth factors in many cell types. In this study, we show that p21ras is a component of the TCR signaling pathway that controls ERK2 activation. In the human Jurkat T cell line, transient expression of constitutively active p21ras induces ERK2 activation, measured as an increase in the ability of an ERK2-tag reporter protein to phosphorylate my...
T cell activation is triggered by antigen stimulation and is characterized by the production of a wi...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
It has been shown previously in T cells that stimulation of protein kinase C or the T cell antigen r...
It has previously been shown in T cells that stimulation of protein kinase C (PKC) or the T cell ant...
It has previously been shown in T cells that stimulation of protein kinase C (PKC) or the T cell ant...
It has previously been shown in T cells that stimulation of protein kinase C (PKC) or the T cell ant...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
T cell activation is triggered by antigen stimulation and is characterized by the production of a wi...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
T cell activation is triggered by antigen stimulation and is characterized by the production of a wi...
T cell activation is triggered by antigen stimulation and is characterized by the production of a wi...
T cell activation is triggered by antigen stimulation and is characterized by the production of a wi...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
It has been shown previously in T cells that stimulation of protein kinase C or the T cell antigen r...
It has previously been shown in T cells that stimulation of protein kinase C (PKC) or the T cell ant...
It has previously been shown in T cells that stimulation of protein kinase C (PKC) or the T cell ant...
It has previously been shown in T cells that stimulation of protein kinase C (PKC) or the T cell ant...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
T cell activation is triggered by antigen stimulation and is characterized by the production of a wi...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
T cell activation is triggered by antigen stimulation and is characterized by the production of a wi...
T cell activation is triggered by antigen stimulation and is characterized by the production of a wi...
T cell activation is triggered by antigen stimulation and is characterized by the production of a wi...
T-lymphocyte activation via the antigen receptor complex (TCR) results in accumulation of p21ras in ...
It has been shown previously in T cells that stimulation of protein kinase C or the T cell antigen r...