Effect of Sex on Reverse Remodeling in Chronic Systolic Heart Failure

Aimo, Alberto
Vergaro, Giuseppe
CASTIGLIONE, VINCENZO
Barison, Andrea
Pasanisi, Emilio
Petersen, Christina
Chubuchny, Vladyslav
Giannoni, Alberto
Poletti, Roberta
MAFFEI, SILVIA
Januzzi, James L.
Passino, Claudio
Emdin, Michele

Open link

Publication date

January 2017

DOI

10.1016/j.jchf.2017.07.011

Publisher

Elsevier BV

ISSN

2213-1779

Citation count (estimate)

Abstract

Objectives This study sought to investigate sex-related differences in reverse remodeling (RR). Background RR, that is, the recovery from left ventricular (LV) dilation and dysfunction in response to treatment for heart failure (HF), is associated with improved prognosis. Methods Data from patients with stable systolic HF (LV ejection fraction [LVEF] of 35%, according to current indication for device implantation, and LVEF <40% or 40% to 50% according to the definition of HF with reduced or mid-range EF). In the whole population, female sex was an independent predictor of RR (hazard ratio: 1.54; 95% confidence interval: 1.11 to 2.14; p = 0.011), together with cause of HF, disease duration, and left bundle branch block. Female sex was again ...