Cationic lipophosphoramidates and lipophosphoguanidines are very efficient for in vivo DNA delivery
- Picquet, E.
- Ny, K.L.
- Delépine, P.
- Montier, T.
- Yaouanc, J.-J.
- Cartier, D.
- Des Abbayes, H.
- Férec, C.
- Clément, J.-C.
DOIAbstract
cited By 50International audienceTwo new families of cationic lipids were designed and synthesized for gene delivery, namely "lipophosphoramidates" and " lipophosphoguanidines", whose efficiency was noteworthy. The most efficient have an arsonium cation as the polar head, and the unsaturated lipidic tails (e.g. oleyl) gave the better in vivo results (mice lungs). © 2005 American Chemical Society
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