Cancer researchers are currently embarking on one of their field's biggest challenges, namely the understanding of how cellular metabolism or certain classes of elite metabolites (e.g., oncometabolites) can directly influence chromatin structure and the functioning of epi-transcriptional circuits to causally drive tumour formation. We here propose that refining the inherent cell attractor nature of nuclear reprogramming phenomena by adding the under-appreciated capacity of metabolism to naturally reshape the Waddingtonian landscape's topography provides a new integrative metabolo-epigenetic model of the cancer stem cell (CSC) theory
The subpopulation of cancer stem cells (CSCs) within tumor bulk are known for tumor recurrence and m...
Epigenetic regulators are one of the most commonly mutated classes of genes in cancer. During cancer...
Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteri...
Cancer researchers are currently embarking on one of their field's biggest challenges, namely the un...
Cancer researchers are currently embarking on one of their field’s biggest challenges, na...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
By impairing histone demethylation and locking cells into a reprogramming-prone state, oncometabolit...
SummaryBy impairing histone demethylation and locking cells into a reprogramming-prone state, oncome...
The acquisition of and departure from stemness in cancer tissues might not only be hardwired by gene...
AbstractThe molecular mechanisms of tumor metastasis remain largely unknown and undefined. A recent ...
By impairing histone demethylation and locking cells into a reprogramming-prone state, oncometabolit...
Generation of cancer stem cell (CSC)-like cells might occur through metabolic corruption of the epig...
International audienceTumor cells display important plasticity potential, which contributes to intra...
Current hypotheses suggest that tumors originate from cells that carry out a process of 'malignant r...
Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells within ...
The subpopulation of cancer stem cells (CSCs) within tumor bulk are known for tumor recurrence and m...
Epigenetic regulators are one of the most commonly mutated classes of genes in cancer. During cancer...
Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteri...
Cancer researchers are currently embarking on one of their field's biggest challenges, namely the un...
Cancer researchers are currently embarking on one of their field’s biggest challenges, na...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
By impairing histone demethylation and locking cells into a reprogramming-prone state, oncometabolit...
SummaryBy impairing histone demethylation and locking cells into a reprogramming-prone state, oncome...
The acquisition of and departure from stemness in cancer tissues might not only be hardwired by gene...
AbstractThe molecular mechanisms of tumor metastasis remain largely unknown and undefined. A recent ...
By impairing histone demethylation and locking cells into a reprogramming-prone state, oncometabolit...
Generation of cancer stem cell (CSC)-like cells might occur through metabolic corruption of the epig...
International audienceTumor cells display important plasticity potential, which contributes to intra...
Current hypotheses suggest that tumors originate from cells that carry out a process of 'malignant r...
Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells within ...
The subpopulation of cancer stem cells (CSCs) within tumor bulk are known for tumor recurrence and m...
Epigenetic regulators are one of the most commonly mutated classes of genes in cancer. During cancer...
Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteri...