The localization and characterization of ischemic scars in relation to the infarct related coronary artery assessed by cardiac magnetic resonance and a novel automatic postprocessing method

This is an open access article originally published in Cardiology Research and Practice; see DOI: http://dx.doi.org/10.1155/2015/120874. Copyright © 2015 Leik Woie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproductio n in any medium, provided the original work is properly cited.Aims . The correspondence between the localization and morphology of ischemic scars and the infarct related artery (IRA) by use of cardiac magnetic resonance imaging and a novel automatic postprocessing method. Methods and Results . Thirty-four patients with one-year-old single IRA myocardial infarction were examined. Endocardium, epicardium, and the point where right and left ventricles are coinciding were manually marked. All measurements were automatically assessed by the method. The following are results with manual assessments of scar properties in parenthesis: mean scar size (FWHM criterion): 7.8 ± 5.5 as %LV (17.4 ± 8.6%); mean endocardial extent of infarction: 44 ± 26 ∘ (124 ± 47 ∘ ); mean endocardial extent of infarction as %LV circumference: 9.7 ± 7.0% (34.6 ± 13.0%); and mean transmurality: 52 ± 20% of LV wall thickness (77 ± 23%).Scarslocatedinsegments1,2,7,8,13,and 14 by use of the automatic method were 96–100% specific for LAD occlusion. The highest specificities of RCA and LCX occlusions were segment 4 with 93% and segment 6 with 64%, respectively. The scar localization assessed automatically or manually was without major differences. Conclusion . The automatic method is applicable and able to assess localization, size, transmurality, and endocardial extent of ischemic scars