XJB-5-131 suppressed the decline in body temperatures in <i>R6/2</i> mice.

<p>Body temperatures were recorded every 2 days from implanted microchips. Temperatures were then averaged per week. Panel A, male mice only; B, female mice only. <i>R6/2</i> mice showed the expected drop in temperatures with age. Treatment with XJB-5-131 maintained temperatures in <i>R6/2</i> mice for longer. * p<0.05, ** p<0.01, *** p<0.001. Grey symbols, WT; white symbols, <i>R6/2</i>-Veh; black symbols, <i>R6/2</i>-XJB. Dotted lines indicate the analysis periods. Data are mean ± SEM. Mouse numbers: 4–8 weeks, WT male, WT female, <i>R6/2</i>-Veh male, <i>R6/2</i>-Veh female, n = 8. <i>R6/2</i>-XJB male, n = 7; <i>R6/2</i>-XJB female, n = 9. 9–12 weeks, all groups n = 6. 13–17 weeks, all groups n = 4. 18 weeks, all groups except <i>R6/2</i>-Veh male, n = 4; <i>R6/2</i>-Veh male, n = 3. 19 weeks, WT male, WT female, <i>R6/2</i>-XJB male, n = 4; <i>R6/2</i>-XJB female, n = 3; <i>R6/2</i>-Veh male, n = 1; <i>R6/2</i>-Veh female, n = 2. 20 weeks, WT male, WT female, n = 4; <i>R6/2</i>-XJB male, <i>R6/2</i>-Veh female, n = 4; <i>R6/2</i>-XJB female, n = 1; <i>R6/2</i>-Veh male, n = 0. 21 weeks, WT male, WT female, n = 4; <i>R6/2</i>-XJB male, n = 2; <i>R6/2</i>-Veh female, <i>R6/2</i>-XJB female, n = 1. 22 weeks, WT male, WT female, n = 4; <i>R6/2</i>-XJB male, <i>R6/2</i>-XJB female, n = 1.