Sequence alignments of mAb 1A4 IgG3, IgG1 and IgG2b variable regions.

<p>The nucleotide sequences of mAbs 1A4 IgG3, IgG1 and IgG2b variable regions were analyzed using IMGT/V-Quest (<a href="http://www.imgt.org" target="_blank">www.imgt.org</a>). The resulting amino acid sequences of heavy chain (<b>Panel A</b>) and light chain (<b>Panel B</b>) framework regions (FR) 1, 2, and 3 and complementarity-determining regions (CDR) 1, 2, and 3 are displayed. The grey highlights indicate the amino acid residues of CDRs.