<p>(A) kcat5 is the rate constant for hydrolysis. (B) Response of the of MAPK pathway when it is disconnected from the rest of the pathway. Sensitivity with respect to k3 which is the rate constant for phoshorylation of MEK. (C) Sensitivity with respect to phosphatase, P’ase 1. (D) Bistability is lost for high levels of phosphatase.</p
<p>The relaxation times of the variables are plotted against the total concentration of phosphatas...
<p>(A, B, C) Simulated Raf, MEK and ERK activities at 10 min when the MAP kinase module was stimulat...
a<p>The steady state(s) for the three models by scanning a)k<sub>1</sub> (SK autophosphorylation rea...
Mitogen-activated protein kinase (MAPK) cascades can operate as bistable switches residing in either...
AbstractMitogen-activated protein kinases are crucial regulators of various cell fate decisions incl...
AbstractA mathematical model is presented of autophosphorylation of Ca2+/calmodulin-dependent protei...
<p>(a) Absolutely bistable models (<i>Bistability</i>>9.5); (b) Bistable models (<i>Bistability</i>>...
<p>A) The concentration of bound ZAP-70 as a function of the relative concentration of active kinase...
(A) A schematic of the phosphorylation module. Autophosphorylation and auto-dephosphorylation of the...
<p>The x- and y-axis show the signal (<i>k<sub>5</sub></i>) level and the corresponding steady state...
<div><p>(A) Phosphorylation of the first subunit is slow at resting Ca<sup>2+</sup> because of the r...
<p>(A) As the phosphotransferase (PT) activity of the sensor kinase changes from saturation (blue cu...
A: State classification indices for Phosphatase1; B: comparison of the output ERK-PP and Phosphatase...
<p>[MP] denotes the concentration of activated myosin phosphatase. The concentration of activated my...
AbstractThe processive phosphorylation mechanism becomes important when there is macromolecular crow...
<p>The relaxation times of the variables are plotted against the total concentration of phosphatas...
<p>(A, B, C) Simulated Raf, MEK and ERK activities at 10 min when the MAP kinase module was stimulat...
a<p>The steady state(s) for the three models by scanning a)k<sub>1</sub> (SK autophosphorylation rea...
Mitogen-activated protein kinase (MAPK) cascades can operate as bistable switches residing in either...
AbstractMitogen-activated protein kinases are crucial regulators of various cell fate decisions incl...
AbstractA mathematical model is presented of autophosphorylation of Ca2+/calmodulin-dependent protei...
<p>(a) Absolutely bistable models (<i>Bistability</i>>9.5); (b) Bistable models (<i>Bistability</i>>...
<p>A) The concentration of bound ZAP-70 as a function of the relative concentration of active kinase...
(A) A schematic of the phosphorylation module. Autophosphorylation and auto-dephosphorylation of the...
<p>The x- and y-axis show the signal (<i>k<sub>5</sub></i>) level and the corresponding steady state...
<div><p>(A) Phosphorylation of the first subunit is slow at resting Ca<sup>2+</sup> because of the r...
<p>(A) As the phosphotransferase (PT) activity of the sensor kinase changes from saturation (blue cu...
A: State classification indices for Phosphatase1; B: comparison of the output ERK-PP and Phosphatase...
<p>[MP] denotes the concentration of activated myosin phosphatase. The concentration of activated my...
AbstractThe processive phosphorylation mechanism becomes important when there is macromolecular crow...
<p>The relaxation times of the variables are plotted against the total concentration of phosphatas...
<p>(A, B, C) Simulated Raf, MEK and ERK activities at 10 min when the MAP kinase module was stimulat...
a<p>The steady state(s) for the three models by scanning a)k<sub>1</sub> (SK autophosphorylation rea...
DOI
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