Additional file 2: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Hoshimi Kawaguchi (5086043)
Isao Matsumoto (12548)
Atsumu Osada (2626765)
Izumi Kurata (5086046)
Hiroshi Ebe (806310)
Yuki Tanaka (112000)
Asuka Inoue (52011)
Naoto Umeda (806312)
Yuya Kondo (186311)
Hiroto Tsuboi (739151)
Yasuhiro Shinkai (1599586)
Yoshito Kumagai (71660)
Akihito Ishigami (275801)
Takayuki Sumida (12557)

Publication date

April 2018

DOI

10.6084/m9.figshare.6126113.v1

Abstract

Figure S2. (a) Padi4 gene expression levels in articular tissue samples from pGIA and control mice, analyzed by qPCR (n = 6). Data are mean Âą SEM. (TIFF 97 kb

Extracted data

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Data Protection

Additional file 2: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Hoshimi Kawaguchi (5086043)
Isao Matsumoto (12548)
Atsumu Osada (2626765)
Izumi Kurata (5086046)
Hiroshi Ebe (806310)
Yuki Tanaka (112000)
Asuka Inoue (52011)
Naoto Umeda (806312)
Yuya Kondo (186311)
Hiroto Tsuboi (739151)
Yasuhiro Shinkai (1599586)
Yoshito Kumagai (71660)
Akihito Ishigami (275801)
Takayuki Sumida (12557)

Open link

Publication date

April 2018

DOI

10.6084/m9.figshare.6126113.v1

Abstract

Figure S2. (a) Padi4 gene expression levels in articular tissue samples from pGIA and control mice, analyzed by qPCR (n = 6). Data are mean Âą SEM. (TIFF 97 kb

Extracted data

Alexandre Denadai-Souza (4091671)
Camilla Ribeiro (4091674)
Corinne Rolland (157856)
Anne Thouard (3275091)
Céline Deraison (4091677)
Cristoforo Scavone (462113)
Daniel Gonzalez-Dunia (61852)
Nathalie Vergnolle (187273)
Maria Avellar (4091680)

June 2017

Effect of lentivirus-mediated heterologous expression of hSPAG11B/C and APC366 in mBSA/IL-β-induced ...

Additional file 1: of Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis

Stephan BlĂźml (3460715)
Emine Sahin (426812)
Victoria Saferding (3583547)
Eliana Goncalves-Alves (3583550)
Eva Hainzl (3583538)
Birgit Niederreiter (170719)
Anastasia Hladik (3583541)
Tobias Lohmeyer (3583544)
Julia Brunner (426811)
Michael Bonelli (170723)
Marije Koenders (3436682)
Wim van den Berg (26110)
Giulio Superti-Furga (207094)
Josef Smolen (898)
Gernot Schabbauer (426813)
Kurt Redlich (2114)

August 2015

(A) BMDCs from wt or myeloid pten -/- animals were analyzed for pten mRNA expression by qPCR. (B) Qu...

Additional file 4: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Hoshimi Kawaguchi (5086043)
Isao Matsumoto (12548)
Atsumu Osada (2626765)
Izumi Kurata (5086046)
Hiroshi Ebe (806310)
Yuki Tanaka (112000)
Asuka Inoue (52011)
Naoto Umeda (806312)
Yuya Kondo (186311)
Hiroto Tsuboi (739151)
Yasuhiro Shinkai (1599586)
Yoshito Kumagai (71660)
Akihito Ishigami (275801)
Takayuki Sumida (12557)

April 2018

Figure S4. (a) Sera of pGIA and control mice obtained at day 14 were separated by SDS-PAGE and stain...

Additional file 3: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Hoshimi Kawaguchi (5086043)
Isao Matsumoto (12548)
Atsumu Osada (2626765)
Izumi Kurata (5086046)
Hiroshi Ebe (806310)
Yuki Tanaka (112000)
Asuka Inoue (52011)
Naoto Umeda (806312)
Yuya Kondo (186311)
Hiroto Tsuboi (739151)
Yasuhiro Shinkai (1599586)
Yoshito Kumagai (71660)
Akihito Ishigami (275801)
Takayuki Sumida (12557)

April 2018

Figure S3. (a) Serum samples obtained at day 14 from pGIA mice. Western blot analysis was performed ...

Additional file 1: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Hoshimi Kawaguchi (5086043)
Isao Matsumoto (12548)
Atsumu Osada (2626765)
Izumi Kurata (5086046)
Hiroshi Ebe (806310)
Yuki Tanaka (112000)
Asuka Inoue (52011)
Naoto Umeda (806312)
Yuya Kondo (186311)
Hiroto Tsuboi (739151)
Yasuhiro Shinkai (1599586)
Yoshito Kumagai (71660)
Akihito Ishigami (275801)
Takayuki Sumida (12557)

April 2018

Figure S1. DBA/1 mice were immunized with pGPI. (a) The clinical score (mean Âą SEM) of pGIA (n = 11...

Additional file 5: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Hoshimi Kawaguchi (5086043)
Isao Matsumoto (12548)
Atsumu Osada (2626765)
Izumi Kurata (5086046)
Hiroshi Ebe (806310)
Yuki Tanaka (112000)
Asuka Inoue (52011)
Naoto Umeda (806312)
Yuya Kondo (186311)
Hiroto Tsuboi (739151)
Yasuhiro Shinkai (1599586)
Yoshito Kumagai (71660)
Akihito Ishigami (275801)
Takayuki Sumida (12557)

April 2018

Figure S5. (a) Liver tissue sections from naĂŻve mice were immunohistochemically stained with anti-I...

Additional file 4: of Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice

Akari Suzuki (137130)
Yuta Kochi (24324)
Hirofumi Shoda (24319)
Yu Seri (3451787)
Keishi Fujio (24320)
Tetsuji Sawada (24323)
Ryo Yamada (8761)
Kazuhiko Yamamoto (8762)

May 2016

Padi2 and Padi4 expression in NK1.1+ cells. mRNA levels were determined by real-time TaqMan RT-PCR u...

Additional file 2: of S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis

Edwin Geven (3469427)
Martijn van den Bosch (3469424)
Irene Di Ceglie (3454922)
Giuliana Ascone (3469421)
Shahla Abdollahi-Roodsaz (531410)
Annet Sloetjes (3469430)
Sven Hermann (1613419)
Michael Schäfers (199804)
Fons van de Loo (3436691)
Peter van der Kraan (3436700)
Marije Koenders (3436682)
Dirk Foell (249589)
Johannes Roth (125060)
Thomas Vogl (125044)
Peter van Lent (383542)

October 2016

(A). Serum levels of the cytokines IL-17, IL-4, and IFN-γ did not correlate with the combined macros...

Additional file 3: of Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice

Akari Suzuki (137130)
Yuta Kochi (24324)
Hirofumi Shoda (24319)
Yu Seri (3451787)
Keishi Fujio (24320)
Tetsuji Sawada (24323)
Ryo Yamada (8761)
Kazuhiko Yamamoto (8762)

May 2016

Padi2 and Padi4 are expressed in the spleens of wild-type mice. (a–e) Immunofluorescence staining (×...

Additional file 1: of S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis

Edwin Geven (3469427)
Martijn van den Bosch (3469424)
Irene Di Ceglie (3454922)
Giuliana Ascone (3469421)
Shahla Abdollahi-Roodsaz (531410)
Annet Sloetjes (3469430)
Sven Hermann (1613419)
Michael SchĂ¤fers (3469433)
Fons van de Loo (3436691)
Peter van der Kraan (3436700)
Marije Koenders (3436682)
Dirk Foell (249589)
Johannes Roth (125060)
Thomas Vogl (125044)
Peter van Lent (383542)

October 2016

(A) Serum S100A8/A9 as a positive marker to predict joint swelling (macroscopic score >0.5) at week ...

Additional file 1: of O-linked N-acetylglucosamine glycosylation of p65 aggravated the inflammation in both fibroblast-like synoviocytes stimulated by tumor necrosis factor-Îą and mice with collagen induced arthritis

Han Kim (3581999)
Sang Won Lee (93576)
Chin Mun (3581990)
Ji Yoon (3486473)
Jaeyoung Pai (1419688)
Injae Shin (1419676)
Yong Beom Park (3581996)
Soo Kon Lee (3581993)
Jin Cho (280173)

September 2015

Primers for RT-PCR. A full list of primers for inflammatory molecules used in RT-PCR. (DOC 30 kb

Additional file 3: of Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug

Gianfranco Caselli (1913095)
Albino Bonazzi (4901713)
Marco Lanza (1913101)
Flora Ferrari (2174444)
Daniele Maggioni (4901728)
Cristian Ferioli (4901725)
Roberto Giambelli (4901701)
Eleonora Comi (4901716)
Silvia Zerbi (4901704)
Marco Perrella (4901731)
Ornella Letari (3017292)
Elena Di Luccio (4901710)
Milena Colovic (4901734)
Stefano Persiani (4901719)
Tiziano Zanelli (4901722)
Laura Mennuni (2174448)
Tiziana Piepoli (4901737)
Lucio Rovati (4901707)

March 2018

Data table showing cytokine serum concentrations (pg/ml) of samples determined from 3-PLEX (MSD) in ...

Additional file 2: of A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease

Eric Hatterer (270252)
Limin Shang (412524)
Pierre Simonet (3505793)
Suzanne Herren (3505790)
Bruno Daubeuf (3505784)
StĂŠphanie Teixeira (3505787)
James Reilly (3319563)
Greg Elson (765745)
Robert Nelson (3447176)
Cem Gabay (642)
Jeremy Sokolove (162190)
Iain McInnes (2063845)
Marie Kosco-Vilbois (139757)
Walter Ferlin (765744)
Emmanuel Monnet (3505799)
Cristina De Min (3505796)

October 2016

Methodological approach used to identify NI-0101 responder samples and biomarkers. RA patient strati...

Additional file 1: of Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study

Alexandre Denadai-Souza (4091671)
Camilla Ribeiro (4091674)
Corinne Rolland (157856)
Anne Thouard (3275091)
Céline Deraison (4091677)
Cristoforo Scavone (462113)
Daniel Gonzalez-Dunia (61852)
Nathalie Vergnolle (187273)
Maria Avellar (4091680)

June 2017

Effect of lentivirus-mediated heterologous expression of hSPAG11B/C and APC366 in mBSA/IL-β-induced ...

Additional file 1: of Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis

Stephan BlĂźml (3460715)
Emine Sahin (426812)
Victoria Saferding (3583547)
Eliana Goncalves-Alves (3583550)
Eva Hainzl (3583538)
Birgit Niederreiter (170719)
Anastasia Hladik (3583541)
Tobias Lohmeyer (3583544)
Julia Brunner (426811)
Michael Bonelli (170723)
Marije Koenders (3436682)
Wim van den Berg (26110)
Giulio Superti-Furga (207094)
Josef Smolen (898)
Gernot Schabbauer (426813)
Kurt Redlich (2114)

August 2015

(A) BMDCs from wt or myeloid pten -/- animals were analyzed for pten mRNA expression by qPCR. (B) Qu...

Additional file 4: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Hoshimi Kawaguchi (5086043)
Isao Matsumoto (12548)
Atsumu Osada (2626765)
Izumi Kurata (5086046)
Hiroshi Ebe (806310)
Yuki Tanaka (112000)
Asuka Inoue (52011)
Naoto Umeda (806312)
Yuya Kondo (186311)
Hiroto Tsuboi (739151)
Yasuhiro Shinkai (1599586)
Yoshito Kumagai (71660)
Akihito Ishigami (275801)
Takayuki Sumida (12557)

April 2018

Figure S4. (a) Sera of pGIA and control mice obtained at day 14 were separated by SDS-PAGE and stain...

Additional file 3: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Hoshimi Kawaguchi (5086043)
Isao Matsumoto (12548)
Atsumu Osada (2626765)
Izumi Kurata (5086046)
Hiroshi Ebe (806310)
Yuki Tanaka (112000)
Asuka Inoue (52011)
Naoto Umeda (806312)
Yuya Kondo (186311)
Hiroto Tsuboi (739151)
Yasuhiro Shinkai (1599586)
Yoshito Kumagai (71660)
Akihito Ishigami (275801)
Takayuki Sumida (12557)

April 2018

Figure S3. (a) Serum samples obtained at day 14 from pGIA mice. Western blot analysis was performed ...

Additional file 1: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Hoshimi Kawaguchi (5086043)
Isao Matsumoto (12548)
Atsumu Osada (2626765)
Izumi Kurata (5086046)
Hiroshi Ebe (806310)
Yuki Tanaka (112000)
Asuka Inoue (52011)
Naoto Umeda (806312)
Yuya Kondo (186311)
Hiroto Tsuboi (739151)
Yasuhiro Shinkai (1599586)
Yoshito Kumagai (71660)
Akihito Ishigami (275801)
Takayuki Sumida (12557)

April 2018

Figure S1. DBA/1 mice were immunized with pGPI. (a) The clinical score (mean Âą SEM) of pGIA (n = 11...

Additional file 5: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Hoshimi Kawaguchi (5086043)
Isao Matsumoto (12548)
Atsumu Osada (2626765)
Izumi Kurata (5086046)
Hiroshi Ebe (806310)
Yuki Tanaka (112000)
Asuka Inoue (52011)
Naoto Umeda (806312)
Yuya Kondo (186311)
Hiroto Tsuboi (739151)
Yasuhiro Shinkai (1599586)
Yoshito Kumagai (71660)
Akihito Ishigami (275801)
Takayuki Sumida (12557)

April 2018

Figure S5. (a) Liver tissue sections from naĂŻve mice were immunohistochemically stained with anti-I...

Additional file 4: of Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice

Akari Suzuki (137130)
Yuta Kochi (24324)
Hirofumi Shoda (24319)
Yu Seri (3451787)
Keishi Fujio (24320)
Tetsuji Sawada (24323)
Ryo Yamada (8761)
Kazuhiko Yamamoto (8762)

May 2016

Padi2 and Padi4 expression in NK1.1+ cells. mRNA levels were determined by real-time TaqMan RT-PCR u...

Additional file 2: of S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis

Edwin Geven (3469427)
Martijn van den Bosch (3469424)
Irene Di Ceglie (3454922)
Giuliana Ascone (3469421)
Shahla Abdollahi-Roodsaz (531410)
Annet Sloetjes (3469430)
Sven Hermann (1613419)
Michael Schäfers (199804)
Fons van de Loo (3436691)
Peter van der Kraan (3436700)
Marije Koenders (3436682)
Dirk Foell (249589)
Johannes Roth (125060)
Thomas Vogl (125044)
Peter van Lent (383542)

October 2016

(A). Serum levels of the cytokines IL-17, IL-4, and IFN-γ did not correlate with the combined macros...

Additional file 3: of Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice

Akari Suzuki (137130)
Yuta Kochi (24324)
Hirofumi Shoda (24319)
Yu Seri (3451787)
Keishi Fujio (24320)
Tetsuji Sawada (24323)
Ryo Yamada (8761)
Kazuhiko Yamamoto (8762)

May 2016

Padi2 and Padi4 are expressed in the spleens of wild-type mice. (a–e) Immunofluorescence staining (×...

Additional file 1: of S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis

Edwin Geven (3469427)
Martijn van den Bosch (3469424)
Irene Di Ceglie (3454922)
Giuliana Ascone (3469421)
Shahla Abdollahi-Roodsaz (531410)
Annet Sloetjes (3469430)
Sven Hermann (1613419)
Michael SchĂ¤fers (3469433)
Fons van de Loo (3436691)
Peter van der Kraan (3436700)
Marije Koenders (3436682)
Dirk Foell (249589)
Johannes Roth (125060)
Thomas Vogl (125044)
Peter van Lent (383542)

October 2016

(A) Serum S100A8/A9 as a positive marker to predict joint swelling (macroscopic score >0.5) at week ...

Han Kim (3581999)
Sang Won Lee (93576)
Chin Mun (3581990)
Ji Yoon (3486473)
Jaeyoung Pai (1419688)
Injae Shin (1419676)
Yong Beom Park (3581996)
Soo Kon Lee (3581993)
Jin Cho (280173)

September 2015

Primers for RT-PCR. A full list of primers for inflammatory molecules used in RT-PCR. (DOC 30 kb

Additional file 3: of Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug

Gianfranco Caselli (1913095)
Albino Bonazzi (4901713)
Marco Lanza (1913101)
Flora Ferrari (2174444)
Daniele Maggioni (4901728)
Cristian Ferioli (4901725)
Roberto Giambelli (4901701)
Eleonora Comi (4901716)
Silvia Zerbi (4901704)
Marco Perrella (4901731)
Ornella Letari (3017292)
Elena Di Luccio (4901710)
Milena Colovic (4901734)
Stefano Persiani (4901719)
Tiziano Zanelli (4901722)
Laura Mennuni (2174448)
Tiziana Piepoli (4901737)
Lucio Rovati (4901707)

March 2018

Data table showing cytokine serum concentrations (pg/ml) of samples determined from 3-PLEX (MSD) in ...

Additional file 2: of A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease

Eric Hatterer (270252)
Limin Shang (412524)
Pierre Simonet (3505793)
Suzanne Herren (3505790)
Bruno Daubeuf (3505784)
StĂŠphanie Teixeira (3505787)
James Reilly (3319563)
Greg Elson (765745)
Robert Nelson (3447176)
Cem Gabay (642)
Jeremy Sokolove (162190)
Iain McInnes (2063845)
Marie Kosco-Vilbois (139757)
Walter Ferlin (765744)
Emmanuel Monnet (3505799)
Cristina De Min (3505796)

October 2016

Methodological approach used to identify NI-0101 responder samples and biomarkers. RA patient strati...

Additional file 1: of Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study

Alexandre Denadai-Souza (4091671)
Camilla Ribeiro (4091674)
Corinne Rolland (157856)
Anne Thouard (3275091)
Céline Deraison (4091677)
Cristoforo Scavone (462113)
Daniel Gonzalez-Dunia (61852)
Nathalie Vergnolle (187273)
Maria Avellar (4091680)

June 2017

Effect of lentivirus-mediated heterologous expression of hSPAG11B/C and APC366 in mBSA/IL-β-induced ...

Additional file 1: of Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis

Stephan BlĂźml (3460715)
Emine Sahin (426812)
Victoria Saferding (3583547)
Eliana Goncalves-Alves (3583550)
Eva Hainzl (3583538)
Birgit Niederreiter (170719)
Anastasia Hladik (3583541)
Tobias Lohmeyer (3583544)
Julia Brunner (426811)
Michael Bonelli (170723)
Marije Koenders (3436682)
Wim van den Berg (26110)
Giulio Superti-Furga (207094)
Josef Smolen (898)
Gernot Schabbauer (426813)
Kurt Redlich (2114)

August 2015

(A) BMDCs from wt or myeloid pten -/- animals were analyzed for pten mRNA expression by qPCR. (B) Qu...

Additional file 2: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Abstract

Extracted data

Additional file 2: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Abstract

Extracted data

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