IS<i>6110</i> in the MTBC.

<p>(<b>a</b>) Schematic phylogenetic relationships of MTBC members arisen from a most recent common ancestor (MRCA) after an evolutionary bottleneck. For <i>M</i>. <i>tuberculosis</i> different lineages and families are indicated. The position of IS<i>6110</i> sequences in fully assembled genomes in indicated by black dots. The arrow indicates the position of IS<i>6110</i> in the Direct Repeat region of the CRISPR-Cas locus, which is common to most MTBC strains. For the remaining 17 <i>M</i>. <i>tuberculosis</i> strains different from H37Rv, the number of IS<i>6110</i> sequences is indicated by a box plot (median = 17). (<b>b</b>) Box plots showing the IS<i>6110</i> copies in MTBC families. For each family, the lineage according to panel (a) is provided in parenthesis in the X-axis. For clarity, L4 have been subdivided into 5 different families according to spoligotyping.