Changes in the ECM are observed in multiple regions of the brain following BCAS.

<p><b>A)</b> Representative images of collagen IV staining (green) within the cortex, hippocampus and striatum of sham or BCAS-treated (7 and 14 days) mice. Scale bar = 100 um. Inset images are a magnified portion to show detail. Scale bar = 300 um. <b>B)</b> Quantification of collagen IV-positive pixels. N = 4–6 **p < 0.01 <b>C)</b> Representative images of alpha5 staining (red) within the cortex, hippocampus and striatum of sham or BCAS treated (7 and 14 days) mice. Scale bar = 100 um. Inset images are a magnified portion to show detail. Scale bar = 300 um. <b>D)</b> Quantification of alpha5-positive pixels. N = 4–6 *p < 0.05.