Association between renal hyperfiltration (RHF) with incident proteinuria.

<p>Upper panel. A reverse J-shaped association between baseline eGFR and the adjusted hazard ratio (aHR) of incident proteinuria. The age-, sex-, body size-, and history of diabetes and hypertension medication-adjusted percentile rank of baseline eGFR was associated with the aHR of incident proteinuria after adjustment for age, sex, smoking status, regular exercise, regular alcohol consumption, known history of diabetes and/or hypertension medication, body mass index, systolic blood pressure, fasting serum glucose, serum triglycerides, and serum high-density lipoprotein-cholesterol. The relationship between the percentile rank of baseline eGFR and the aHR of incident proteinuria was evaluated with a general additive model. The shaded area represents the 95% confidence interval. Lower panel. Association between RHF (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0195784#sec002" target="_blank">Methods</a> for details) and aHR of incident proteinuria. The age-, sex-, body size-, and history of diabetes and hypertension medication-adjusted RHF was associated with the aHR of incident proteinuria after adjustment for age, sex, smoking status, regular exercise, regular alcohol consumption, known history of diabetes and/or hypertension medication, body mass index, systolic blood pressure, fasting serum glucose, serum triglycerides, and serum high-density lipoprotein-cholesterol.