___Background:___ Hardcore smokers have little to no intention to quit smoking. These ‘hardcore smokers’ are hard to reach by current tobacco control measures, and are particularly vulnerable to death and disease. In our multi-study research project, we developed and tested an online intervention that involves hardcore smokers in tobacco control. ___Methods and results:___ In study 1, we found that the prevalence of hardcore smoking in the Dutch general population decreased from 12.2% in 2001 to 8.2% in 2012. In study 2, we conducted 11 focus groups among current and former hardcore smokers, and distinguished 6 themes in the pros and cons of smoking and quitting: Finance, Health, Intrapersonal Processes, Social Environment, Physical En...