Unraveling Molecular Mechanisms Underlying Alzheimer’s disease and its Related Endophenotypes

Dementia and its most common type, Alzheimer’s disease (AD) is a devastating disease that afflicts millions worldwide. Still, there are no targeted preventive interventions or pharmacological treatments for AD available. This makes further unraveling the pathophysiology of AD to find new targets for treatment a global research priority. Genetic research has played a pivotal role to identify novel insights in the pathophysiology of AD and has influenced clinical diagnostics and treatment developments. Therefore, the overarching aim of the studies included in this thesis is to gain novel insights in the molecular and biological mechanisms underlying AD and its related endophenotypes using genetic research. The studies that make up this thesis are organized in chapters that all approach this goal from a different angle